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In Vivo Hemoglobin Thiyl Radical Formation as a Consequence of Hydrazine-Based Drug Metabolism

  • Ronald P. Mason
  • Kirk R. Maples
Part of the NATO ASI Series book series (NSSA, volume 197)

Abstract

For a variety of reasons, the possibility of free radical metabolism has not received much attention in the past, although Michaelis of the Michaelis-Menten equation was interested in free radical metabolites and their importance in biochemistry in the 1930’s. One reason for the late development of this area is that most biochemicals, as opposed to aromatic drugs and industrial chemicals, are not easily metabolized through free radical intermediates. Another reason is that unless something can be demonstrated with a whole animal, there will always be some question of its actual existence in biology. To detect something as ephemeral as a free radical formed inside a whole animal is certainly not easy. In such investigations, the toxic effects of free radicals are presumably the result of purely chemical reactions; therefore, a knowledge of the radical’s chemistry under physiological conditions is necessary.

Keywords

Spin Adduct Radical Adduct Free Radical Intermediate Free Radical Metabolism Nitroxide Free Radical 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Ronald P. Mason
    • 1
  • Kirk R. Maples
    • 1
  1. 1.Laboratory of Molecular BiophysicsNational Institute of Environmental Health SciencesUSA

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