Electrochemistry of Thioethers as Models for Biological Electron Transfer

  • George S. Wilson
Part of the NATO ASI Series book series (NSSA, volume 197)


Considering the importance of sulfur in biological systems, it is somewhat surprising that thioethers have only recently received attention from the point of view of their redox chemistry. In terms of biological function, there are perhaps three classes of interactions in which they are involved. The first case involves their role as a part of metal centers in redox-active proteins. Examples include cytochrome c where histidine and methionine comprise the two axial ligands in an iron porphyrin, co-factors in methanogenic bacteria F-420 (S-Ni coordination)1 and in the Type I “Blue Copper” proteins.2 Examples of this latter group include azurin and plastocyanin. In the latter case the immediate coordination around Cu(II) is one cysteine thiolate (S at 2.1 Å), two histidine imidazoles (N at 2.05 Å and 2.10 Å), and a methionine sulfur (at 2.9 Å) in a distorted trigonal pyramidal array.


Electron Transfer Rate Iron Porphyrin Blue Copper Cysteine Thiolate Spiro Compound 


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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • George S. Wilson
    • 1
  1. 1.Department of ChemistryUniversity of KansasLawrenceUSA

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