Advertisement

Vision and Visual Discrimination Suffer in Parkinson’s Disease: Evoked Potential Evidence

  • I. Bodis-Wollner
  • S. Pang
  • A. Falk
  • M. F. Ghilardi
  • L. Mylin
Part of the Advances in Behavioral Biology book series (ABBI, volume 39)

Abstract

Patients affected by Parkinson’s Disease (PD) not infrequently complain of some visual difficulty yet their visual acuity is intact. Although on careful questioning “double vision” may clarify itself as perceiving uncertain borders of images, more complex complaints cannot be easily classified as “visual” or as “cognitive” defects. In fact, both have been demonstrated in PD. While spatial frequency dependent visual defects probably result from retinal dopaminergic (DA) deficiency, the anatomy and neuropharmacology of cognitive changes in PD is uncertain.

Keywords

Visual Evoke Potential Visual Deficit Late Positive Component Late Visual Evoke Potential Cortical Visual Evoke Potential 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    I. Bodis-Wollner, 1990, Visual deficits related to dopamine deficiency in experimental animals and Parkinson’s Disease patients, Trends in Neuroscience, in press.Google Scholar
  2. 2.
    I. Bodis-Wollner and M.D. Yahr, 1978, Measurement of visual evoked potentials in Parkinson’s disease, Brain, 101: 661–671.PubMedCrossRefGoogle Scholar
  3. 3.
    I. Bodis-Wollner, 1990, The visual system in Parkinson’s Disease, in: “Vision and the Brain,” B. Cohen and I. Bodis-Wollner, eds., Raven Press, New York.Google Scholar
  4. 4.
    A. Tartaglione, N. Pizio, I. Bo, L. Spadavecchia, and E. Favale, 1985, Spatial properties of pattern as determinants of visual evoked potential changes in Parkinson’s syndrome, in: “Evoked potentials: neurophysiological and clinical aspects,” C. Morocutti and P.A. Rizzo, eds., Elsevier, Amsterdam.Google Scholar
  5. 5.
    M. Onofrj, M.F. Ghilardi, M. Basciani, and Gambi D., 1986, Visual evoked potentials in Parkinson’s disease and dopamine blockade reveal a stimulus-dependent dopamine function in humans, J Neurol Neurosurq Psychiatry, 49: 1150–1159.CrossRefGoogle Scholar
  6. 6.
    P. Stanzione, F. Pierelli, A. Peppe, P.A. Rizzo, and C. Morocutti, 1989, Pattern visual evoked potentials and electroretinogram abnormalities in Parkinson’s disease: effects of L-dopa therapy, Clin Vis Sci, 4: 115–128.Google Scholar
  7. 7.
    P.A. Bhaskar, S. Vanchilingam, E.A. Bhaskar, A. Devaprabhu, and R.A. Ganesan, 1988, Effect of L-dopa on visual evoked potentials in patients with Parkinson’s disease, Neurology, 36: 1119–1121.CrossRefGoogle Scholar
  8. 8.
    I. Bodis-Wollner, M. Yahr, L. Mylin, and J. Thornton, 1982, Dopaminergic deficiency and delayed visual evoked potentials in humans, Ann. Neurol., 11: 478–483.PubMedCrossRefGoogle Scholar
  9. 9.
    I. Bodis-Wollner, M.S. Marx, S. Mitra, P. Bobak, L. Mylin, and M. Yahr, 1987, Visual dysfunction in Parkinson’s disease, Brain, 110: 1675–1698.PubMedCrossRefGoogle Scholar
  10. 10.
    A.P. Mariani and J.N. Hokoc, 1988, Two types of tyrosine hydroxylase-immunoreactive amacrine cell in the rhesus monkey retina, J. Comp. Neurol., 276: 81–91.PubMedCrossRefGoogle Scholar
  11. 11.
    D. Regan and C. Maxner, 1987, Orientation-selection visual loss in patients with Parkinson’s disease, 1987, Brain, 110: 415–432.PubMedCrossRefGoogle Scholar
  12. 12.
    C. Bulens, J.D. Meerwaldt, G.J. van der Wildt, and C.K. Keemink, 1986, Contrast sensitivity in Parkinson’s disease, Neurology, 36: 1121–1125.PubMedCrossRefGoogle Scholar
  13. 13.
    A. Benton, K. Hamsher, N. Varney, and O. Spreen, 1983, “Contributions to Neuropsychological Assessment: A Clinical Manual,” Oxford University Press, New York.Google Scholar
  14. 14.
    F. Bowen, M. Burus, E. Brady, and M.D. Yahr, 1972, A note on alterations of personal orientation in parkinsonism, Neuropsychologia, 14: 425–429.CrossRefGoogle Scholar
  15. 15.
    S. Sutton, M. Braren, and J. Zubin, 1965, Evoked potential correlates of stimulus uncertainty, Science, 150: 1187–1188.PubMedCrossRefGoogle Scholar
  16. 16.
    M.M. Hoehn and M.D. Yahr, 1967, Parkinsonism: onset, progression and mortality, Neurology, 17: 427–442.PubMedCrossRefGoogle Scholar
  17. 17.
    I. Bodis-Wollner, L. Mylin, and S. Frkovic, 1989, The topography of the N70 component of the visual evoked potential in humans, in: “Topographic Brain Mapping of EEG and Evoked Potentials,” K. Maurer, ed., Springer-Verlag, Berlin.Google Scholar
  18. 18.
    T. Malmfors, 1963, Evidence of adrenergic neurons with synaptic terminals in the retina of rats demonstrated with fluorescence and electron microscopy, Acta Physiol. Scand., 64: 58–66.Google Scholar
  19. 19.
    R.S. Dyer, W.E. Howell, and R.C. McPhail, 1981, Dopamine depletion slows retinal transmission, Exp. Neurol., 71: 326–340PubMedCrossRefGoogle Scholar
  20. 20.
    M. Onofrj and I. Bodis-Wollner, 1982, Dopaminergic deficiency causes delayed visual evoked potentials in rats, Ann. Neurol., 11: 484–490.PubMedCrossRefGoogle Scholar
  21. 21.
    M.F. Ghilardi, M.S. Marx, I. Bodis-Wollner, C.B. Camras, and A. Glover, 1989, The effect of intraocular 6hydroxydopamirie on retinal processing of primates, Ann. Neurol., 25: 357–364.PubMedCrossRefGoogle Scholar
  22. 22.
    M.F. Ghilardi, E. Chung, I. Bodis–Wollner, M. Dvorzniak, A. Glover, and M. Onofrj, 1988, Systemic 1–methyl, 4–phenyl, 1–2–3–6–tetrahydropyridine (MPTP) administration decreases retinal dopamine content in primates, Life Sci., 43: 255 – 262.PubMedCrossRefGoogle Scholar
  23. 23.
    M.S. Marx, I. Bodis-Wollner, P. Bobak, C. Harnois, L. Mylin, and M. Yahr, 1986, Temporal frequency-dependent VEP changes in Parkinson’s Disease, Vision Res., 26: 185–193.PubMedCrossRefGoogle Scholar
  24. 24.
    S.A. Raskin, J.C. Borod, J. Wasserstein, I. BodisWollner, L. Coscia, and M.D. Yahr, 1990, Visuospatial orientation in Parkinson’s Disease, Int. J. Neurosci., 51: 9–18PubMedCrossRefGoogle Scholar
  25. 25.
    A.M. Gotham, R.G. Brown, and C.D. Marsden, 1988, ‘Frontal’ cognitive function in patients with Parkinson’s Disease ’On’ and ’Off’ levodopa, Brain, 111:299–321.Google Scholar
  26. 26.
    S. Funahashi, C.J. Bruce, and P.S. Goldman-Rakic, 1989, Mnemonic coding of visual space in the monkey’s dorsolateral prefrontal cortex, J. Neurophysiology, 61, 331–349.Google Scholar
  27. 27.
    L.D. Selemon and P.S. Goldman-Rakic, 1988, Common cortical and subcortical targets of the dorsolateral prefrontal and posterior parietal cortices in the rhesus monkey: evidence for a distributed neural network subserving spatially guided behavior, J. Neurosci., 8 (11): 4049–4068.PubMedGoogle Scholar
  28. 28.
    E. Halgren, N.K. Squires, C.L. Wilson, J.R. Rohrbaugh, T.L. Babb, and P.H. Crandall, 1980, Endogenous potentials generated in the human hippocampal formation and amygdala by infrequent events, Science, 210: 803–805.PubMedCrossRefGoogle Scholar
  29. 29.
    E.C. Hansch, K. Syndulko, S.S.N. Cohen, Z.I. Goldberg, A.R. Potvin, and W.W. Tourellotte, 1982, Cognition in Parkinson’s disease: An event-related potential perspective, Ann. Neurol., 11: 599–607.Google Scholar
  30. 30.
    D.S. Goodin and M.J. Aminoff, 1987, Electrophysiological differences between demented and nondemented patients with Parkinson’s disease, Ann. Neurol., 21 (1): 90–94.PubMedCrossRefGoogle Scholar
  31. 31.
    I. Bodis-Wollner, M.D. Yahr, and L.H. Mylin, 1984, Nonmotor functions of the basal ganglia, in:“Advances in Neurology”, R.G. Hassler and J.R. Christ, eds., Raven Press, New York.Google Scholar
  32. 32.
    S. Pang, J.C. Borod, I. Bodis-Wollner, S. Raskin, L. Mylin, L. Coscia, and M.D. Yahr, 1990, The auditory P300 correlates with specific cognitive deficits in Parkinson’s disease, J. Neural Transm., in press.Google Scholar
  33. 33.
    G. Kass, 1988, Electrophysiological and psychophysical investigation of spatial contrast discrimination in human vision, doctoral dissertation, I. Bodis-Wollner, supervisor, University of Michigan, Ann Arbor, Microfilm file. Acknowledgement: This work was partially supported by EY01708, NS-11631, and NIH-ST35DK07420.Google Scholar

Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • I. Bodis-Wollner
    • 1
    • 2
  • S. Pang
    • 1
  • A. Falk
    • 1
  • M. F. Ghilardi
    • 1
  • L. Mylin
    • 1
  1. 1.The VEP Laboratory, Department of Neurology, Themount Sinai School of MedicineCUNYNew YorkUSA
  2. 2.Department of Ophthalmology, Themount Sinai School of MedicineCUNYNew YorkUSA

Personalised recommendations