Complementarity of the Two Pallidal Segments in the Primate

  • Michel Filion
  • Léon Tremblay
  • Vijayakumar Chockkan
Part of the Advances in Behavioral Biology book series (ABBI, volume 39)


In the present volume, Parent and collaborators demonstrate that the neurons of the internal (GPi) and external (GPe) segments of the primate globus pallidus differ fundamentally with respect to their afferent and efferent connections, in spite of their virtually identical morphology and chemospecificity. To develop further this anatomical point of view, the present paper reviews recent findings of physiological differences between the two pallidal segments in monkeys. Those differences are clearly revealed when the dopaminergic innervation of the basal ganglia is destroyed, quite specifically, by the neurotoxin 1-methyl4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), which renders the animal parkinsonian. We submit that GPi and GPe constitute a matching, contrasting and complementary pair of structures.


Firing Rate Subthalamic Nucleus High Firing Rate Dark Neuron Pallidal Neuron 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Michel Filion
    • 1
  • Léon Tremblay
    • 1
  • Vijayakumar Chockkan
    • 1
  1. 1.Centre de Recherche en NeurobiologieUniversité Laval et Hôpital de l’Enfant-JésusQuébec, Qué.Canada

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