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Course of Motor and Cognitive Impairment in Huntington’s Chorea

  • F. Girotti
  • D. Oliva
  • V. Fetoni
  • D. Testa
  • P. Soliveri
  • P. Giovannini
  • G. Geminiani
  • T. Caraceni
Part of the Advances in Behavioral Biology book series (ABBI, volume 39)

Abstract

Motor impairment, mental decay and psychopathological abnormalities all contribute to functional disability in Huntington’s Chorea (HC) (1–3) though Mayeux et al (4) concluded that a major role is played by intellectual derangement.

Keywords

Movement Time Huntington Disease Cognitive Disorder Neuropsychological Deficit Basal Ganglion Lesion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Caine E.D Ebert MJ, Weingartner H. An outline for the analysis of dementia: the memory disorder of huntington’s disease. Neurology 27: 1087–1092, 1977.PubMedCrossRefGoogle Scholar
  2. 2.
    Brandt J, Strauss ME, Larus J et al: Clinical correlates of dementia and disability in Huntington’s disease. J Clin Neuropsychol 6 (4): 401–412 (1984).PubMedCrossRefGoogle Scholar
  3. 3.
    Caine ED, Hunt RD, Weingartner H, Ebert MJ: Huntington’s dementia. Arch Gen Psychiatry 35: 377–384 (1978).PubMedCrossRefGoogle Scholar
  4. 4.
    Mayeux R, Stern Y, Herman A, Greenbaum L, Fahn S. Correlates of early disability in Huntington’s disease. Ann Neurol 20: 727–731 (1986).PubMedCrossRefGoogle Scholar
  5. 5.
    Bruyn GW. Huntington’s chorea: historical, clinical and laboratory synopsis, in: “Handbook of Clinical Neurology”, Vol 6, Vinken PJ, Bruyn JW eds. Amsterdam: North-Holland, pp 298–378 (1968).Google Scholar
  6. 6.
    Shoulson I. Care of patients and families with Huntington’s disease. in: “Movement Disorders”, Marsden CD and Fahn S eds. London: Butterworth, pp 277–290 (1982).Google Scholar
  7. 7.
    Hefter H, Homberg V, Lange HW, Freund HJ. Impairment of rapid movement in Huntington’s disease. Brain 110: 585–612 (1987).PubMedCrossRefGoogle Scholar
  8. 8.
    Thompson PD, Berardelli A, Rothwell JC, Day BL, Dick JPR, Benecke R, Marsden CD. The coexistence of bradykinesia and chorea in Huntington’s disease and its implications for theories of basal ganglia control movement. Brain 11: 223244 (1988).Google Scholar
  9. 9.
    Marsden CD. Slowness of movement in Parkinson’s disease. Movement disorders. 4 (Suppl 1): 26–37 (1989).CrossRefGoogle Scholar
  10. 10.
    Girotti F, Marano R, Soliveri P, Geminiani G, Scigliano G. Relationship between motor and cognitive disorders in Huntington’s disease. J Neurol 235: 454–457 (1988).PubMedCrossRefGoogle Scholar
  11. 11.
    Shoulson I, Fahn S. Huntington disease: clinical care and evaluation. Neurology 29: 1–3 (1979).PubMedCrossRefGoogle Scholar
  12. 12.
    Girotti F, Carella F, Scigliano G, Grassi MP, Soliveri F, Giovannini P, Parati E, Caraceni T. Effect of neuroleptìc treatment on involuntary movements and motor performances in Huntington’s disease. J Neurol Neurosurg Psychiatry 47: 848–852 (1984).PubMedCrossRefGoogle Scholar
  13. 13.
    Wechsler D. The Wechsler Adult Intelligence Scale“. New York Psychological Corporation (1955).Google Scholar
  14. 14.
    American Psychiatric Association “Diagnostic and Statistical Manual of Mental Disorders”. 3rd ed. American Psychiatric Association. Washington D.C. (1980).Google Scholar
  15. 15.
    Aminoff MJ, Marshall J, Smith F. Pattern of intellectual impairment in Huntington chorea. Psychol Med 5: 169–172 (1975).PubMedCrossRefGoogle Scholar
  16. 16.
    Norton JC. Patterns of neuropsychological test performance in Huntington’s disease. J Nery Ment Dis 161: 276–279 (1975).CrossRefGoogle Scholar
  17. 17.
    Fedio P, Cox CS, Neophytides A, Canal-Frederick G, Chase PN. Neuropsychological profile of Huntington’s disease: patients and those at risk, in: “Adv Neurol”, Vol 23 Chase TN, Wexler NS, Barbeau A, eds.. New York: Raven Press. pp 449–556 (1979).Google Scholar
  18. 18.
    Brandt J, Folstein SE, Folstein MF. Differential cognitive impairment in Alzheimer’s disease and Huntington’s disease. Ann Neurol 23: 555–561 (1988).PubMedCrossRefGoogle Scholar
  19. 19.
    Butters N, Sax D, Montgomery K, Tarlow S. Comparison of the neuropsychological deficits associated with early and advanced Huntington’s disease. Arch Neurol 35: 585–589 (1978).PubMedCrossRefGoogle Scholar
  20. 20.
    Josiassen RC, Curry LM, Mancall EL. Development of neuropsychological deficits in Huntington’s disease. Arch Neurol 40: 791–796 (1983).PubMedCrossRefGoogle Scholar
  21. 21.
    Huber SJ, Paulson GW. Memory impairment associated with progression of Huntington’s disease. Cortex 23; 27–283 (1987).Google Scholar
  22. 22.
    Kerr B. Task factors that influence selection and preparation for voluntary movements, in: “lnformartion Processing in Motor Control and Learning. Stelmach GE eds. New York, London: Academic Press, pp 55–69 (1978).Google Scholar

Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • F. Girotti
    • 1
  • D. Oliva
    • 1
  • V. Fetoni
    • 1
  • D. Testa
    • 1
  • P. Soliveri
    • 1
  • P. Giovannini
    • 1
  • G. Geminiani
    • 1
  • T. Caraceni
    • 1
  1. 1.Istituto Neurologico C. GestaMilanItaly

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