Treatment of Motor Fluctuations in Parkinson’s Disease: Controlled Release Preparations
The fundamental problem in the treatment of Parkinson’s disease is the appearance of motor fluctuations after long-term drug therapy (long-term L-dopa treatment syndrome, LTS, Marsden and Parkes, 1976). The clinical manifestations of LTS are complex, consisting of a varying association of akinetic symptoms and dyskinesias whose pathogenesis has still not been clarified.
KeywordsMotor Fluctuation Control Release Form Target Symptom Dopaminergic Stimulation Slow Release Formulation
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