Advances in the Understanding of Neural Mechanisms in Movement Disorders

  • I. J. Mitchell
  • J. M. Brotchie
  • W. C. Graham
  • R. D. Page
  • R. G. Robertson
  • M. A. Sambrook
  • A. R. Crossman
Part of the Advances in Behavioral Biology book series (ABBI, volume 39)


Relatively little is known about how various primary pathologies within the basal ganglia manifest themselves in the appearance of movement disorders. For example, both Parkinson’s disease and Huntington’s disease are characterised by dysfunction of the striatum. In the case of Parkinson’s disease, loss of the ascending dopamine systems results in disordered striatal activity, whereas in Huntington’s disease, parts of the striatum degenerate. It is implicitly assumed that the abnormal movements result from the disordered striatal activity acting on lower motor centres, presumably via the intermediary of the thalamus and its connections with the cortex. However, the pathophysiological processes by which the abnormal striatal output acts upon the intervening basal ganglia nuclei are yet to be defined. In an attempt to address these issues we have developed primate models of a spectrum of movement disorders and then attempted to both elucidate the neural circuitry which is responsible for mediating them and to define the underlying characteristic changes in neural activity in each of the affected basal ganglia nuclei.


Tardive Dyskinesia Excitatory Amino Acid Globus Pallidus Subthalamic Nucleus Kynurenic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    CARPENTER, M.B. & SUTIN J. (1983) Human Neuroanatomy, Williams & Wilkins, Baltimore/London.Google Scholar
  2. 2.
    CROSSMAN, A.R., SAMBROOK, M.A. A& JACKSON, A. (1984) Brain, 107, 579 - 596.PubMedCrossRefGoogle Scholar
  3. 3.
    SOKOLOFF L., REIVICH M., KENNEDY C., DES ROSIERS M. H., PATLACK C. S., PETTIGREW K. D., SAKURADA O. and SHINOHARA M. J. Neurochem., 1977; 28, 897 - 916.PubMedCrossRefGoogle Scholar
  4. 4.
    MITCHELL I.J., SAMBROOK M.A. AND CROSSMAN A.R. Brain, 1985; 108, 405 - 422.PubMedCrossRefGoogle Scholar
  5. 5.
    AUKER, C.R, MESZLER, R.M. AND CARPENTER, D.O. J. Neurophysiol., 1983; 49: 1504PubMedGoogle Scholar
  6. 6.
    MATA M., FINK D.J., GAINER H., SMITH C.B., DAVIDSEN L., SAVAKI H., SCHWARTZ W. J. & SOKOLOFF L. J. Neurochem., 1980; 34, 213 - 215.PubMedCrossRefGoogle Scholar
  7. 7.
    SCHWARTZ W.J., SMITH C.B., DAVIDSEN L., SAVAKI H. AND SOKOLOFF L. Science, 1979; 205, 723 - 725.PubMedCrossRefGoogle Scholar
  8. 8.
    GROSSMAN, A.R., MITCHELL, I.J., JACKSON, A. & SAMBROOK, M.A. (1988) Brain, 111, 1211 - 1233.CrossRefGoogle Scholar
  9. 9. MITCHELL, I.J., JACKSON, A., SAMBROOK, M.A. AND CROSSMAN, A.R. Brain, (In press).Google Scholar
  10. 10.
    PARENT, A., (1986) Comparative Neurobiology of the Basal Ganglia, John Wiley.Google Scholar
  11. 11.
    GUNNE, L.M., HAGGSTROM, J.E. & SJOQUIST, B. (1984) Nature, 309: 347 - 349.PubMedCrossRefGoogle Scholar
  12. 12.
    MITCHELL, I.J., PAGE, R.D., ROBERTSON, R.G., CROSSMAN, A.R. & GUNNE, L.M. Br. J. Pharmacol., (In press)Google Scholar
  13. 13.
    BOYCE, S., CLARKE, C.E., LUQUIN, R., PEGGS, D., FARMERY, S.M., ROBERTSON, R.G., MITCHELL, I J, SAMBROOK, M.A. AND CROSSMAN, A.R. Movement Disorders (In press)Google Scholar
  14. 14.
    ILINSKY, I.A & KULTAS-ILINSKY 1987 J. Comp. Neurol. 262: 331 - 364.PubMedCrossRefGoogle Scholar
  15. 15. MITCHELL, I.J., CLARKE, C.E., BOYCE, S., ROBERTSON, R.G., PEGGS, D., SAMBROOK, M.A. AND GROSSMAN, A.R. Neuroscience (In press).Google Scholar
  16. 16.
    AUGOOD, S.J., EMSON, P.C., MITCHELL, I J, BOYCE, S., CLARKE, C.E. AND CROSSMAN, A.R. 1989 Mol. Brain Res., 6, 85 - 92.PubMedCrossRefGoogle Scholar
  17. 17.
    Classification of Extrapyramidal Disorders J. Neurol. Sci., 1981; 51, 311 - 327.Google Scholar
  18. 18.
    MITCHELL, I.J., LUQUIN, R., BOYCE, S., CLARKE, C.E., ROBERTSON, R.G., SAMBROOK, M.A. & CROSSMAN, A.R. Movement Disorders, (In press)Google Scholar
  19. 19.
    MILLER, W.C. & DELONG, M.R. (1987) In: Advances in Behavioural Biology, 32, The Basal Ganglia II. Structure and Function - Current Concepts (Carpenter M.B. & Jayaraman A., eds.) Plenum Press, New York, 395 - 403.Google Scholar
  20. 20.
    FILION, M., TREMBLAY, L. & BEDARD, P.J. (1988) Brain Res., 444: 165 - 176.PubMedCrossRefGoogle Scholar
  21. 21.
    SMITH, Y. & PARENT, A. (1988) Brain Res., 453: 353 - 356.PubMedCrossRefGoogle Scholar
  22. 22.
    KITA, H. & KITAI, S.T. (1987) J. Comp. Neurol. 260: 435 - 452.PubMedCrossRefGoogle Scholar
  23. 23.
    BROTCHIE, J.B., CROSSMAN, A.R. Br. J. Pharmacol. (In press)Google Scholar
  24. 24.
    ROBERTSON, R.G., FARMERY, S.M., SAMBROOK, M.A. & CROSSMAN, A.R. (1989) Brain Res. 476: 317 - 322PubMedCrossRefGoogle Scholar
  25. 25.
    BROTCHIE, J.B., MITCHELL, I.J. & CROSSMAN, A.R. Eur. J. Pharmacol (Submitted)Google Scholar

Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • I. J. Mitchell
    • 1
  • J. M. Brotchie
    • 1
  • W. C. Graham
    • 1
  • R. D. Page
    • 1
  • R. G. Robertson
    • 1
  • M. A. Sambrook
    • 1
  • A. R. Crossman
    • 1
  1. 1.Experimental Neurology Group Department of Cell and Structural BiologyUniversity of ManchesterManchesterUK

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