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Role of D1 and D2 Dopamine Receptors in Pilocarpine-Induced Seizures

  • Paolo Barone
  • Vincenzo Palma
  • Sotirios A. Parashos
  • Thomas N. Chase
  • Giuseppe Campanella
Part of the Advances in Behavioral Biology book series (ABBI, volume 39)

Abstract

Both substantia nigra (SN) and caudate-putamen (CP) are brain regions documented to be involved in the regulation of seizure susceptibility (Gale, 1984). Nigral microinjection of gamma-amino-butyric-acid (GABA) agonists or antagonists respectively attenuates or potentiates seizures in several experimental models of epilepsy (Iadarola and Gale, 1982; Turski et al., 1986, 1987a). Similarly, pilocarpine induced-seizures convulsions are prevented by chemical stimulation of striatal cells but facilitated by lesioning of the caudateputamen (Turski et al., 1987b).

Keywords

Substantia Nigra Status Epilepticus Convulsive Activity Electrographic Seizure Pilocarpine Injection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Paolo Barone
    • 1
  • Vincenzo Palma
    • 1
  • Sotirios A. Parashos
    • 2
  • Thomas N. Chase
    • 2
  • Giuseppe Campanella
    • 1
  1. 1.Institute of Neurology, II Faculty of MedicineUniversity of NaplesItaly
  2. 2.Experimental Therapeutics BranchNINCDSBethesdaUSA

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