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Effects of Transient Global Ischemia on the Basal Ganglia of Rat

  • R. Schmidt-Kastner
  • W. Paschen
  • K.-A. Hossmann
Part of the Advances in Behavioral Biology book series (ABBI, volume 39)

Summary

The present studies focussed upon the effect of transient global brain ischemia on basal ganglia of rat. A modified four-vessel occlusion (4VO) model was used to induce forebrain ischemia. Regional cerebral blood flow was severely depressed in the striatum during 4VO. Biochemical measurements revealed a massive depletion of energy-rich metabolites in the striatum during ischemia which was followed by a transient recovery of energy metabolism. Neuropathological studies demonstrated early and massive lesions in the striatum. Damage increased from ventral to dorso-lateral areas of the striatum which may be related both to variations in the microcirculatory disturbances and to differences in intrinsic neuronal organization. Immunohistochemical studies showed a depression of staining for astrocytes and formation of vasogenic edema in the dorso-lateral striatum.

Keywords

Glial Fibrillary Acidic Protein Globus Pallidus Regional Cerebral Blood Flow Lateral Area Large Neuron 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • R. Schmidt-Kastner
    • 1
  • W. Paschen
    • 1
  • K.-A. Hossmann
    • 1
  1. 1.Dep. Experimental NeurologyMax-Planck-Institut für neurologische ForschungKöln 91FR Germany

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