Summary
The present studies focussed upon the effect of transient global brain ischemia on basal ganglia of rat. A modified four-vessel occlusion (4VO) model was used to induce forebrain ischemia. Regional cerebral blood flow was severely depressed in the striatum during 4VO. Biochemical measurements revealed a massive depletion of energy-rich metabolites in the striatum during ischemia which was followed by a transient recovery of energy metabolism. Neuropathological studies demonstrated early and massive lesions in the striatum. Damage increased from ventral to dorso-lateral areas of the striatum which may be related both to variations in the microcirculatory disturbances and to differences in intrinsic neuronal organization. Immunohistochemical studies showed a depression of staining for astrocytes and formation of vasogenic edema in the dorso-lateral striatum.
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© 1991 Plenum Press, New York
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Schmidt-Kastner, R., Paschen, W., Hossmann, KA. (1991). Effects of Transient Global Ischemia on the Basal Ganglia of Rat. In: Bernardi, G., Carpenter, M.B., Di Chiara, G., Morelli, M., Stanzione, P. (eds) The Basal Ganglia III. Advances in Behavioral Biology, vol 39. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5871-8_62
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DOI: https://doi.org/10.1007/978-1-4684-5871-8_62
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