L-DOPA-Induced Chorea and Dystonia in MPTP-Treated Squirrel Monkeys
Administration of L-DOPA to Parkinsonian patients frequently induces a range of disabling involuntary movements of which chorea and dystonia are the most common. Choreiform movements are often associated with peak plasma levels of drug (‘peak-dose dyskinesias’; Markham, 1974) suggesting an association with the antiparkinsonian action of L-DOPA. In contrast, dystonias are less predictable, being prevalent not only during the time of peak effect but also while plasma L-DOPA levels are rising and falling (‘diphasic dyskinesias’; Barbeau, 1975; Muenter et al, 1977).
KeywordsLocomotor Activity Squirrel Monkey Vehicle Treatment Abnormal Involuntary Movement Scale Choreiform Movement
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