Retrograde Axonal Transport of MPTP after Unilateral Caudate Nucleus Infusion in the Monkey
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) elicits selective destruction of nigrostriatal dopamine neurons in human and non-human primates along with clinical symptoms of Parkinson’s disease (Langston et al., 1983; Burns et al., 1983). Systemically administered MPTP is biotransformed into 1-methyl-4-phenylpyridium ion (MPP+), which then enters dopaminergic neurons via the dopamine uptake system to destroy nigral cells.
KeywordsTyrosine Hydroxylase Ventral Tegmental Area Caudate Nucleus Infusion Site Locus Ceruleus
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- Burns, R.S., Chiueh, C.C., Markey, S.P., Ebert, M.H., Jacobowitz, D.M. and Kopin, I.J., 1983, A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the sub-stantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Proc. Natl. Acad. Sci. U.S.A., 80: 4546.PubMedCrossRefGoogle Scholar