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Retrograde Axonal Transport of MPTP after Unilateral Caudate Nucleus Infusion in the Monkey

  • Hisamasa Imai
  • Toshiki Nakamura
  • Nobuo Miyashita
  • Katsunori Nishi
  • Hirotaro Narabayashi
Part of the Advances in Behavioral Biology book series (ABBI, volume 39)

Abstract

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) elicits selective destruction of nigrostriatal dopamine neurons in human and non-human primates along with clinical symptoms of Parkinson’s disease (Langston et al., 1983; Burns et al., 1983). Systemically administered MPTP is biotransformed into 1-methyl-4-phenylpyridium ion (MPP+), which then enters dopaminergic neurons via the dopamine uptake system to destroy nigral cells.

Keywords

Tyrosine Hydroxylase Ventral Tegmental Area Caudate Nucleus Infusion Site Locus Ceruleus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Hisamasa Imai
    • 1
  • Toshiki Nakamura
    • 1
  • Nobuo Miyashita
    • 1
  • Katsunori Nishi
    • 1
  • Hirotaro Narabayashi
    • 1
  1. 1.Department of NeurologyJuntendo University School of MedicineTokyoJapan

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