Organization of Cholinergic Perikarya in the Caudate Nucleus of the Cat with Respect to Heterogeneities in Enkephalin and Substance P Staining

  • Maryann E. Martone
  • Stephen J. Young
  • David M. Armstrong
  • Philip M. Groves
Part of the Advances in Behavioral Biology book series (ABBI, volume 39)


We present here a series of studies examining the organization of cholinergic perikarya in the caudate nucleus of the cat and their relationship to heterogeneities observed in enkephalin and substance P staining. Cholinergic interneurons comprise only a small proportion of the total number of striatal cells (Phelps et al., 1985). Most studies have not reported any obvious organization in the distribution of these cells in single sections (Fibiger, 1982) although some authors have commented that they did not appear to be evenly distributed but were organized into poorly defined clusters (Everitt et al., 1988; Mesulam et al., 1984). In addition, no consistent relationship has been demonstrated between the cholinergic perikarya and the striosomal compartment as delineated by acetylcholinesterase. While cholinergic neuropil and the high affinity choline uptake system are distributed primarily within the matrix (Graybiel et al., 1986; Rhodes et al., 1987), cholinergic cell bodies have been reported to occur both within patch and matrix in equal densities (Brand, 1980) or to be slightly increased in density within the matrix compartment (Graybiel et al., 1983, 1986).


Caudate Nucleus Cholinergic Neuron Dorsal Striatum Cholinergic Cell Striatal Cell 


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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Maryann E. Martone
    • 1
  • Stephen J. Young
    • 1
  • David M. Armstrong
    • 2
  • Philip M. Groves
    • 1
  1. 1.Departments of Psychiatry and NeuroscienceUniversity of California San DiegoSan DiegoUSA
  2. 2.Georgetown Institute of NeurosciencesFIDIAUSA

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