Specifically Evoked Release of Newly Synthesized or Stored Dopamine by Different Treatments
It is now well admitted that intraterminal dopamine (DA) is distributed between various compartments. Numerous studies have been devoted to the problem of the DA compartmentation (Javoy and Glowinski, 1971; Groppetti et al., 1977, Mc Millen et al., 1980) and we have recently proposed a new functional model of the intraterminal organization of the metabolic pathways leading to the synthesis and the release of DA (Leviel et al., 1989). In brief, the greatest part of the amine appears to be stored; besides, the newly synthesized molecules constitute a second pool under close dependence of the synthesis and being the first to be released under basal conditions (Besson et al.,1969; Leviel and Guibert, 1987). In consequence, an evoked overflow of DA could result from the involvement of either the stored or the newly synthesized amine.
KeywordsTyrosine Hydroxylase Caudate Nucleus Impulse Flow Presynaptic Regulation Potassium Application
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