Influence of Cortico-Striatal Glutamatergic Neurons on Dopaminergic Transmission in the Striatum

  • J. Glowinski
  • L. Barbeito
  • A. Cheramy
Part of the Advances in Behavioral Biology book series (ABBI, volume 39)


Several studies performed on rat striatal slices and in some cases on synaptosomes have indicated that dopamine (DA) and most neurotransmitters found in the striatum regulate presynapticaily the release of DA from nerve terminals of the nigro-striatal DA neurones (chesselet, 1984). These neurotransmitters include excitatory or inhibitory amino-acids, amines and several neuropeptides found either in afferent fibers, interneurones or in collaterals of efferent projections from the striatum. These regulations are either direct or indirect, ie mediated through receptors located on DA nerve terminals or on neurones in contact with these nerve terminals. This has been mainly shown by examining the persistance or disappearance of these presynaptic regulations in the presence of tetrodotoxin (TTX), a neurotoxine which interrupts nerve impulse flow. There is some evidence that some neurotransmitters may diffuse at some distance from their release sites before their inactivation. Nevertheless, the physiological significance of some presynaptic regulations of DA release has been often challenged by neuroanatomists since up to now few axo-axonic contacts have been observed between DA neurones and other neurones innervating the striatum (Bouyer et al., 1984). In vivo studies, in which identified pathways projecting to the striatum can be activated are of great value for determining the physiological relevance of these presynaptic regulations. Therefore, we will first summurize results of in vivo experiments made in halothane anesthetized cats implanted with push-pull cannulae which have allowed to demonstrate the role of the corticostriatal glutamatergic projection in the presynaptic control of DA release. We will also describe more recent experiments made either in vivo or in vitro in which attempts were made to identify the types of glutamatergic receptors involved in the presynaptic control of DA release and to distinguish direct and indirect effects mediated by local circuits.


Nerve Terminal Caudate Nucleus Dopamine Release Local Circuit Diethyl Ester 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Barbeito, L., Cheramy, A., Godeheu, G., Desce, J.M. and Giowinski, J. 1990, Glutamate receptors of the quisqualate-kainate subtype are involved in the presynaptic regulation of dopamine release in the cat caudate nucleus in vivo, Eur. J. Neuroscience, (in press)Google Scholar
  2. Barbeito, L., Girault, J.A., Godeheu, G., Pittaluga, A., Glowinski, J., and Cheramy, A., 1989, Activation of the bilateral cortico-striatal glutamatergic projection by infusion of GABA into thalamic motor nuclei in the cat:an in vivo release study. Neuroscience, 28:365–374.PubMedCrossRefGoogle Scholar
  3. Bolam, J.P. 1984, Synapses of identified neurons in the neostriatum. in: Functions of the Basal Ganglia (eds Evered D. and O’Connors M. ) pp 30–47, Pitman, London.Google Scholar
  4. Bouyer, J.J., Park, D.H., Joh, T.H., and Pickel, V.M., 1984, Chemical and structural analysis of the relation between cortical inputs and tyrosine hydroxylase-containing terminals in rat neostriatum. Brain Res., 302: 267–275.PubMedCrossRefGoogle Scholar
  5. Cheramy, A., Romo, R., Godeheu, G., Baruch, P., and Glowinski, J., 1986, In vivo presynaptic control of dopamine release in the cat caudate nucleus; II. Facilitatory or inhibitory influence of L-glutamate. Neuroscience, 12: 1081–1090.CrossRefGoogle Scholar
  6. Chesselet, M.F., 1984, Presynaptic regulation of neurotransmitter release in the brain: Facts and hypothesis. Neuroscience, 12: 347–275.PubMedCrossRefGoogle Scholar
  7. Gercer., C.R., 1984, The neostriatal mosaic: Compartmentalisation of corticostriatal input and striatal output systems. Nature, 311: 461–463.CrossRefGoogle Scholar
  8. Giorguieff, M.F., Kernel, M.L., and Glowinski, J., 1977, Presynaptic effect of L-glutamic acid on the release of dopamine in rat striatal slices. Neurosci. Lett. 6: 73–77.CrossRefGoogle Scholar
  9. Graybiel, A.M., 1986, Neuropeptides in the basal ganglia. in: Neuropeptides in Neurologic and Psychiatric Diseases ( J.B. Martin and J.D. Barchas, Eds.), Raven Press, New York, pp 135–161.Google Scholar
  10. Krebs, M.O., Kernel, M.L., Gauchy, C., Desban, M., and Giowinski, J., 1986, Glycine potentiates the NMDAinduced release of dopamine through a strychnine-insensitive site in the rat striatum. Europ. J. Pharmacol., 166: 567–570.CrossRefGoogle Scholar
  11. Nieoullon, A., Cheramy, A., and Glowinski, J., 1978, Release of dopamine evoked by electrical stimulation of the motor and visual areas of the cerebral cortex in both caudate nuclei and in the substantia nigra in the cat. Brain Res., 145: 69–83.PubMedCrossRefGoogle Scholar
  12. Roberts, P.J., and Anderson, S.D., 1979, Stimulatory effect of L-glutamate and related amino acids on 3H-dopamine release from rat striatum: an in vitro model for glutamate actions. J. Neurochem. 32: 1539–1545.PubMedCrossRefGoogle Scholar
  13. Roberts, P.J., and Sharif, N.A., 1978, Effects of L-glutamate and related amino acids upon the release of 3H-dopamine from rat striatal slices. Brain Res., 157: 391–395.PubMedCrossRefGoogle Scholar
  14. Romo, R., Cheramy, A., Godeheu, G., and Glowinski, J., 1984, Distinct commissural pathways are involved in the enhanced release of dopamine induced in the contralateral caudate nucleus and substantia nigra by the unilateral application of GABA in the cat thalamic motor nuclei. Brain Res., 308: 43–52.PubMedCrossRefGoogle Scholar
  15. Romo, R., Cheramy, A., Godeheu, G., and Glowinski, J., 1986a, In vivo presynaptic control of dopamine release in the cat caudate nucleus: I. Opposite changes in neuronal activity and release evoked from thalamic motor nuclei. Neuroscience, 19: 1091–1099.CrossRefGoogle Scholar
  16. Romo, R., Cheramy, A., Godeheu, G., and Glowinski, J., 1986b, In vivo presynaptic control of dopamine release in the cat caudate nucleus. III. Further evidence for the implication of cortico-striatal glutamatergic neurons. Neuroscience, 19: 1091–1099.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • J. Glowinski
    • 1
  • L. Barbeito
    • 1
  • A. Cheramy
    • 1
  1. 1.College de France — Inserm U 114 11, place Marcelin BerthelotParis cedex 05France

Personalised recommendations