Comparative Distribution of D1 Receptors and μ Opiate Receptors in the Neonatal Rat Striatum: Effects of an Early Lesion of Dopaminergic Fibers

  • Monique Rogard
  • Jocelyne Caboche
  • Marie-Jo Besson
Part of the Advances in Behavioral Biology book series (ABBI, volume 39)


The compartmental organization of the striatum in striosomes and matrix (Graybiel and Ragsdale, 1978) is followed by a large variety of neuronal markers. Peptide-containing fibers and peptide-containing perikarya (Graybiel and Ragsdale, 1983; Graybiel, 1984a), afferent fibers (Gerfen et al., 1987a; Gerfen, 1989; Jimenez-Castellanos and Graybiel, 1987) efferent neurons (Jimenez-Castellanos and Graybiel, 1989), are mostly distributed according to this two compartments. Various specific receptor ligands have also been shown to label binding sites organized according to a striosomal pattern, as for instance μ opiate receptors (Herkenham and Pert, 1981), muscarinic M1 receptors (Nastuk and Graybiel, 1985), benzodiazepine type II sites (Faull and Villiger, 1988). With regard to dopamine (DA) receptors, a compartmental distribution has been observed in the striatum of cat and monkey, with heightened density of Dl receptors (Besson et al., 1988) in striosomes and heightened density of D2 receptors in the matrix (Beckstead et al., 1988). No such heterogeneity has been described for Dl or D2 receptors in the striatum of the adult rat (Boyson et al., 1986; Savasta et al., 1986). However, it has been shown in feline (Richfield at al., 1987) and rodents (Murrin and Zeng, 1989; Ohta and al., 1989) that both striatal DA fibers and striatal D1 receptors are clustered during the neonatal period. The purpose of our study was to reexamine, in the rat striatum, the postnatal evolution of the distribution of Dl receptors, and to analyze the possible role of the incoming DA fibers in the disappearance of their patchy organization. The distribution of D1 receptors was compared to that of μ opiate receptors during the first three postnatal weeks in intact rats and in rats treated at postnatal day 2 (P2) by an intrastriatal 6-OHDA injection.


Tyrosine Hydroxylase Dorsal Striatum Opiate Receptor Intact Side AChE Staining 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Monique Rogard
    • 1
  • Jocelyne Caboche
    • 1
  • Marie-Jo Besson
    • 1
  1. 1.Laboratoire de Neurochimie-AnatomieIDN-CNRSParisFrance

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