Correlated Light and Electron Microscopy of Golgi-Impregnated Neostriatal Neurons after 6-Hydroxydopamine Lesions in the Rat

  • C. A. Ingham
  • S. H. Hood
  • G. W. Arbuthnott
Part of the Advances in Behavioral Biology book series (ABBI, volume 39)


The removal of the dopamine input to the neostriatum by 6-hydroxydopamine lesions is a useful method of studying possible neuronal responses which may occur in the neostriatum in Parkinson’s disease. We have shown that medium size spiny neurons have a lower spine density in the neostriatum which has lost its dopamine input compared with the control unlesioned neostriatum (Ingham et al., 1989). This result persists to the same degree at relatively short and long time periods after the lesion. The present study expands on these results and takes the same material to the electron microscope for ultrastructural evaluation.


Spine Density Ultrastructural Evaluation Medium Size Spiny Neuron Asymmetrical Synaptic Contact Lower Spine Density 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • C. A. Ingham
    • 1
  • S. H. Hood
    • 1
  • G. W. Arbuthnott
    • 1
  1. 1.Department of Preclinical Veterinary Sciences R(D)SVSUniversity of EdinburghSummerhall EdinburghUK

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