Cholinergic Excitation of A9 and A10 Dopaminergic Neurones in Vitro through Both Nicotinic and Muscarinic Receptors

  • M. G. Lacey
  • P. Calabresi
  • R. A. North
Part of the Advances in Behavioral Biology book series (ABBI, volume 39)


There are no cholinergic neurones within either substantia nigra (A9) or ventral tegmental (A10) area (Mesulam et al., 1983). However choline acetyltransferase-immunoreactive terminals within substantia nigra pars compacta have been observed (Beninato & Spencer, 1988). Such innervation may arise from the cholinergic neurones of the pedunculopontine nucleus (PPN) (Woolfe & Butcher, 1986; Clarke et al., 1987; but see Lee et al., 1988).


Muscarinic Receptor Voltage Clamp Pedunculopontine Nucleus Neuronal Nicotinic Receptor Nicotinic Response 


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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • M. G. Lacey
    • 1
    • 2
  • P. Calabresi
    • 1
    • 3
  • R. A. North
    • 1
  1. 1.Vollum InstituteOregon Health Sciences UniversityPortlandUSA
  2. 2.Department of PharmacologySmith Kline & French Research Ltd.Welwyn HertsUK
  3. 3.II Universita degli Studi di RomaRomeItaly

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