Dopamine D1 Receptors and Terminal Excitability in the Striatonigral and Nigrostriatal Systems
The terminal excitability method, pioneered by Wall (1958) to investigate the mechanisms of presynaptic inhibition in the spinal cord, is an electrophysiological procedure for observing the consequences of stimulation of receptors on axon terminals in vivo. In this technique, a stimulating electrode is placed in the vicinity of the axon terminal field in order to electrically elicit an antidromic response that is detected with a microelectrode located at the soma. The effects of terminal receptor stimulation or blockade are observed as a change in the threshold current just sufficient to elicit an antidromic response.
KeywordsSubstantia Nigra Axon Terminal Gaba Release Presynaptic Receptor Endogenous Dopamine
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