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Short-Term Plasticity in the Ventral Striatum a Comparision between in Vivo and in Vitro Measurements

  • P. H. Boeijinga
  • F. H. Lopes da Silva
  • C. M. A. Pennartz
Part of the Advances in Behavioral Biology book series (ABBI, volume 39)

Abstract

In order to understand how information from the subiculum is mediated by way of the nucleus accumbens (Acb) to more caudally lying areas, it is of importance to know how the limbic inputs affect Acb output neurons. Here we report experiments using electrophysiological recording techniques and stimulation of the subiculum-accumbens pathways (i.e. the fornix) under various conditions to address this question. De France et al. (1985a) investigated a possible interaction between successive responses using paired pulse stimulation with intervals in the range of 10–40 ms. They showed that the response to the second, or test stimulus was suppressed at intervals below 30 ms. In a separate paper (De France et al. 1985b) these authors reported a suppressive effect of dopamine on the responses when the input fibers were stimulated once every 1–2 s. For stimulation with a rate of 6 pulses/s (intervals 167 ms) no such effect was found. The subiculum is a part of the hippocampal formation, that is known to have EEG activity predominantly in the theta range (4–12 Hz). Therefore, the transmission of the signals in the subiculum-accumbens pathways may be frequency-dependent.

Keywords

Conditioning Stimulus Nucleus Accumbens Test Stimulus Input Fiber Theta Range 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Boeijinga, P.H., Pennartz, C.M.A. and Lopes da Silva, F.H., 1990, Paired-pulse facilitation in the nucleus accumbens following stimulation of subicular inputs in the rat. Neurosci., In press.Google Scholar
  2. Creager, R., Dunwiddie,T. and Lynch,G., 1980, Paired-pulse and frequency facilitation in the CA1 region of the in vitro rat hippocampus, J.Phyiol., 299: 409Google Scholar
  3. De France, J.F., Marchand, J.F., Sikes, R.W., Chronister,R.B. and Hubbard, J.I., 1985a, Characterization of fimbria input to nucleus accumbens, J.Neurophysinl., 54: 1553.Google Scholar
  4. De France, J.F., Sikes, R.W. and Chronister,R.B., 1985b, Dopamine action in the nucleus accumbens, J.Neurophysiol., 54: 1568.Google Scholar

Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • P. H. Boeijinga
    • 1
  • F. H. Lopes da Silva
    • 1
  • C. M. A. Pennartz
    • 1
  1. 1.Dept. Exp.ZoologyUniversity of AmsterdamAmsterdamThe Netherlands

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