Dye-Coupling in the Neostriatum of the Rat
Morphologically, gap junctions are intermembranous channels between cells thought to mediate electrotonic transmission and to serve as a passage for small molecules in the CNS (for a review see Sotelo and Korn, 1978). After the discovery that the fluorescent dye Lucifer yellow crosses gap junctions to label adjacent cells (Stewart, 1978), dye-coupling was used as indirect evidence for the presence of gap junctions. Dye-coupling occurs in several neural areas, including the hippocampus (Knowles et el., 1982; MacVicar et al., 1982), the neocortex (Connors et al., 1983; Gutnick and Prince, 1981) and the hypothalamus (Andrew et al., 1981; Hatton et al., 1987). In parallel ultrastructural studies, gap junctions have been shown to be present in some of these structures (Sloper and Powell, 1978; Sotelo and Korn, 1978).
KeywordsHorizontal Cell Dopamine Concentration Lucifer Yellow Postnatal Development Electrolytic Lesion
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- Baker, R. and Minds, R., 1971, Electrotonic coupling between neurons in the rat mesencephalic nucleus, J. Physiol. (Lond)., 212:45–63.Google Scholar
- Bennett, M.V.L., Spray, D.C. and Harris, A.L., 1981, Electrical coupling in development, Amer. Zool., 21: 413 – 427. Google Scholar
- Bennett, M.V.L., Verselis, V., White, R.L. and Spray, D.C., 1988, Gap Junctional Conductance: Gating. In: Modern Cell Biology. Vol. 7. Gap Junctions. E.L. Hertzberg and R.G. Johnson (eds.) A.R. Liss, Inc. New York, pp 287 – 304.Google Scholar
- Brown, M.C. and Hardman, V.J., 1987, Plasticity of vertebrate motoneurons. In: Growth and plasticity of neural connections. W. Winlow and C.R. McCrohan (eds.). Manchester University Press, pp. 36 – 55. Google Scholar
- Dowling, J.E., 1986, Dopamine: a retina neuromodulator? TINS. 9: 236 – 240. Google Scholar
- Dudek, F.E., Andrew, R.D., MacVicar, B.A., Snow, R.W. and Taylor, C.P. 1983, Recent evidence for and possible significance of gap junctions and electrotonic synapses in the mammalian brain. In H.H. Jasper and N.M. vanGelder (Eds.), Basic mechanisms of neuronal hyper-excitability, Alan R. Liss, New York, pp. 31 – 73.Google Scholar
- Hornykiewicz, 0., 1982, Brain neurotransmitter changes in Parkinson's disease. In: Marsden, C.D and Fahn, S. (eds.), Movement disorders, Butterworth Scientific, London, pp. 41 – 58.Google Scholar
- Llinâs, R.R., 1985, Electrotonic transmission in the mammalian central nervous system. In: Gap Junctions. Eds. M.V.L. Bennett and D.C. Spray, Cold Spring Harbor Laboratory, pp. 337 – 353.Google Scholar
- Pannese, E., Luciano, L. and Reale, E., 1978, Intercellular junctions in developing spinal ganglion, Zool., 6: 129 – 138.Google Scholar
- Rogawski, M.A., 1987, New directions in neurotransmitter action: Dopamine provides some important clues, TINS., 10: 200 – 205.Google Scholar
- Santiago, M., Cano, J., Machado, A. and Reinoso-Suarez, F., 1987, Postnatal development in the monoamine content in the striatum of the rat, Biogenic Amines. 4: 381 – 389.Google Scholar
- Tennyson, V.M., Barrett, R.E., Cohen, G., Cote, L., Heikkila, R. and Mytilineou, C., 1972, The developing neostriatum of the rabbit: Correlation of fluorescence histochemistry, electron microscopy, endogenous dopamine levels, and [3H] dopamine uptake, Brain Res., 46: 251 – 285.PubMedCrossRefGoogle Scholar