The Ultrastructural Chemoanatomy of the Basal Ganglia: 1984–1989. I. The Neostriatum
Our last review on the ultrastructural chemoanatomy of the basal ganglia (Pasik et al., 1986) covered the articles published through part of 1984. In our concluding remarks, we emphasized that the significant gaps in our knowledge at the time, could be expected to be filled by the application of new techniques that were just beginning to show some success. They were: (1) the development of antibodies directed against small molecules such as the neuroactive substances, as opposed to their synthesizing enzymes; (2) the use of more subtle markers such as ferritin or gold particles, which do not obscure the subcellular details of labeled structures; and (3) the possibility of differentially visualizing more than one substance in the same preparation, thereby improving the chances for the discovery of the interactions which characterize the neuronal circuits operating in the basal ganglia.
KeywordsAxon Initial Segment Proximal Dendrite Striatal Cell Dendritic Shaft Asymmetric Synapse
Dopamine beta hydroxylase
Calcitonin gene-related peptide
Gamma aminobutyric acid
Nicotinamide adenine dinucleotide phosphate-diaphorase
Substantia nigra, pars compacta
Substantia nigra, pars lateralis
Substantia nigra, pars reticulata
Vasoactive intestinal polypeptide
Ventral tegmental area
Wheat germ agglutinin
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