Convergent Projections from Substantia Nigra and Cerebellum on Pontine Reticular Formation of Rat
Although basal ganglia and cerebellum represent two important motor structures, few data exist in literature regarding their cooperation in motor control. The only recent papers on reciprocal influences between these structures regard the control exerted by paleostriatum on neocerebellar neurons (Perciavalle et al., 1987) and the projections from intracerebellar nuclei to the dopaminergic structures of ventral midbrain tegmentum (Perciavalle et al., 1989). Cerebellum and basal ganglia could cooperate by sending their outputs on common motor targets, as thalamic nuclei controlling cortical motor areas or spinal-projecting brainstem structures. At thalamic level, no evidence has been found for convergence of cerebellar inputs on those neurons controlled by basal ganglia (Ueki et al., 1977; Uno and Yoshida, 1975). On the other hand, it has been demonstrated that cerebellar lateral nucleus (LN; Bantli and Bloedel, 1975) and pars reticulata of substantia nigra (SN; Perciavalle, 1987) are capable of exerting monosynaptic influences on single spinal-projecting neurons of pontomedullary reticular formation (RF). However, it is not yet known whether these cerebellar and nigral projections reach separate populations of RF cells or control the same RF neurons.
KeywordsReticular Formation Interpositus Nucleus Ketamine Hydrochloride Anesthesia Pontine Reticular Formation Terminal Label
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