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Studies of Evolving Carbohydrate Metabolism invivo by 13C Surface-Coil NMR Spectroscopy

  • Nancy N. Becker
  • Joseph J. H. Ackerman
Part of the Basic Life Sciences book series (BLSC, volume 56)

Abstract

The capability of NMR spectroscopy to study biological systems noninvasively was extended to whole animal applications by the introduction of the surface-coil receiver by Ackerman et al. (1980). While this first demonstration utilized a 31P-tuned receiver for the detection of phosphorus signals, the technique has been extended to other nuclides, including proton ( 1H) and fluorine (19F), and, in conjunction with proton-decoupling, carbon ( 13C).

Keywords

Glycogen Synthesis Hepatic Glycogen Substrate Mixture Glycogen Particle Label Glucose 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Ackerman, J. J. H., Grove, T. H., Wong, G. C., Gadian, D. G., and Radda, G. K., 1980, Nature (Lond.), 283:167–170.CrossRefGoogle Scholar
  2. Cohen, S. M., Ogawa, W., and Shulman, R. G., 1979, Proc. Nat. Acad. Sci. USA, 76:1603PubMedCrossRefGoogle Scholar
  3. Cohen, S. M., Shulman, R. G., and McLaughlin, A. C., 1979, ibid, 76:4808.Google Scholar
  4. Kotyk, J., Deuel, R. K., and Ackerman, J. J. H., 1989, J. Neurochem, 53:1620–1628.PubMedCrossRefGoogle Scholar
  5. Kuwajima, M., Newgard, C. B., Foster, D. W., and McGarry, J. D., 1984, J. Biol. Chem., 261:8849–8853.Google Scholar
  6. Reo, N. V., Ewy, C. S., Siegfried, B. A., and Ackerman, J. J. H., 1984a, J. Magn. Reson., 58:76–84.Google Scholar
  7. Reo, N. V., Siegfried, B. A., and Ackerman, J. J. H., 1984b, J. Biol. Chem., 259:13664–13667.PubMedGoogle Scholar
  8. Shalwitz, R. A., Reo, N. V., Becker, N. N., and Ackerman, J. J. H., 1987, Magn. Reson. Med., 5:462–465.PubMedCrossRefGoogle Scholar
  9. Shalwitz, R. A., Reo, N. V., Becker, N. N., Hill, A. C., Ewy, C. S., and Ackerman, J. J. H., 1989, J. Biol. Chem., 264:3930–3934.PubMedGoogle Scholar
  10. Shulman, G. I., Rothman, D. L., Smith, D., Johnson, C. M., Blair, J. B., Shulman, R. G., and DeFronzo, R. A., 1985, J. Clin. Invest., 76:1229–1236.PubMedCrossRefGoogle Scholar
  11. Siegfried, B. A., Reo, N. V., Ewy, C. S., Shalwitz, R. A., Ackerman, J. J. H., and McDonald, J. M., 1985, J. Biol. Chem., 260:16137–16142.PubMedGoogle Scholar
  12. Sillerud, L. O., and Shulman, R. G., 1983, Biochemistry, 22:1087.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Nancy N. Becker
    • 1
  • Joseph J. H. Ackerman
    • 1
  1. 1.Department of ChemistryWashington UniversitySt. LouisUSA

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