Regeneration of Skeletal Muscle Fibers after Necrosis
I am going to review the normal process of regeneration after necrosis in skeletal muscle and compare it with what happens in Duchenne dystrophy. Dr. Karpati and I have devised an experimental method for producing a focal lethal injury of skeletal muscle qells in which the sequence of steps can be closely followed. We call it experimental micropuncture injury, because the muscle cells are transfixed by a fine tungsten wire with a 10µm tip. All fibers that are pierced go on to necrosis.
KeywordsSatellite Cell Duchenne Dystrophy Basal Lamina Muscle Regeneration Neural Cell Adhesion Molecule
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