Regeneration of Skeletal Muscle Fibers after Necrosis

  • Stirling Carpenter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 280)


I am going to review the normal process of regeneration after necrosis in skeletal muscle and compare it with what happens in Duchenne dystrophy. Dr. Karpati and I have devised an experimental method for producing a focal lethal injury of skeletal muscle qells in which the sequence of steps can be closely followed. We call it experimental micropuncture injury, because the muscle cells are transfixed by a fine tungsten wire with a 10µm tip. All fibers that are pierced go on to necrosis.


Satellite Cell Duchenne Dystrophy Basal Lamina Muscle Regeneration Neural Cell Adhesion Molecule 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Stirling Carpenter
    • 1
  1. 1.Montreal Neurological InstituteMcGill UniversityMontrealCanada

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