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MDX Mouse as Therapeutic Model System: Development and Implementation of Phenotypic Monitoring

  • Michael S. Hudecki
  • Catherine M. Pollina
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 280)

Abstract

As Michael Brooke so aptly stated at the beginning of this session on phenotypic monitoring, it is imperative to have a quantifiable test system in place prior to assessing treatment entities for any of the muscular dystrophies (Brooke et al., 1981). In this manner, the various medical, experimental, and ethical considerations have been resolved in advance providing an unequivocal foundation for determining efficacy (regardless of the particular therapeutic approach under consideration). Similarly, in the preclinical study of myopathic animal models, it is equally pertinent to establish reliable phenotypic endpoints before the implementation of a therapeutic study. Hence, efficacy or a lack thereof can be objectively and rationally determined against a backdrop of standardized markers of the disease.

Keywords

Muscular Dystrophy Duchenne Dystrophy Spinal Muscular Atrophy Duchenne Muscular Dystrophy Activity Chamber 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Michael S. Hudecki
    • 1
  • Catherine M. Pollina
    • 1
  1. 1.Department of Biological SciencesState University of New York at BuffaloUSA

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