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Retroviral Lineage Markers for Assessing Myoblast Fate In Vivo

  • Helen M. Blau
  • Simon M. Hughes
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 280)

Abstract

Using a retroviral marking system, we are monitoring normal muscle development in vivo. In contrast to other reports in this volume in which the fate of myoblasts that were injected into animals was followed, we have followed the fate of the animal’s own myoblasts. Specifically, the question we are asking is: Do satellite cells migrate from one fiber to another? This, of course, is an important consideration in myoblast therapy, since the hope is that the injected myoblasts will be able to migrate and participate in myofiber formation at a distance.

Keywords

Satellite Cell Basal Lamina Multiple Fiber Label Fiber Myoblast Transplantation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Helen M. Blau
    • 1
  • Simon M. Hughes
    • 1
  1. 1.Department of PharmacologyStanford University School of MedicineStanfordUSA

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