Localization of Muscle Gene Products in Nuclear Domains: Does this Constitute a Problem for Myoblast Therapy?

  • Helen M. Blau
  • Grace K. Pavlath
  • Kevin Rich
  • Steven G. Webster
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 280)

Abstract

A question of major interest in considering myoblast therapy is whether the gene product dystrophin, provided by the introduced myoblasts, can contribute to the function of the myofiber into which the cells fuse. As shown in several papers in this volume, there is now ample evidence that injected myoblasts can fuse with myofibers and produce dystrophin, but the question of whether that dystrophin can restore muscle function still remains. In this regard, a major consideration is whether dystrophin can gain access to distant sites within the myofiber or remains localized in the vicinity of the nucleus that encoded it.

Keywords

Polyethylene Glycol Creatine Fluorescein Isothiocyanate 

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Helen M. Blau
    • 1
  • Grace K. Pavlath
    • 1
  • Kevin Rich
    • 1
  • Steven G. Webster
    • 1
  1. 1.Department of PharmacologyStanford University School of MedicineStanfordUSA

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