Control of Satellite Cell Proliferation

  • Richard Bischoff
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 280)


Satellite cells are reserve stem cells of adult skeletal muscle and thus represent a potential source of myogenic cells to use in myoblast replacement therapy of neuromuscular disease. Optimal application of this strategy requires knowledge of factors that control the growth and differentiation of satellite cells. Control of satellite cell proliferation is a complex phenomenon determined by the contribution of both positive and negative factors (Fig. 1).


Satellite Cell Basal Lamina Myogenic Cell Muscle Extract Satellite Cell Proliferation 
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  1. Allen, R. E. and Boxhorn, L. K., 1989, Regulation of skeletal-muscle satellite cell-proliferation and differentiation by transforming growth factor-beta, insulin-like growth factor-I, and fibroblast growth-factor, J. Cell. Physiol., 138: 311.PubMedCrossRefGoogle Scholar
  2. Allen, R. E., Dodson, M. V., and Luiten, L. S., 1984, Regulation of skeletal muscle satellite cell proliferation by bovine pituitary fibroblast growth factor, Exp. Cell Res., 152:154.PubMedCrossRefGoogle Scholar
  3. Bischoff, R., 1986a, Proliferation of muscle satellite cells on intact myofibers in culture, Dev. Biol., 115:129.PubMedCrossRefGoogle Scholar
  4. Bischoff, R., 1986b, A satellite cell mitogen from crushed adult muscle, Dev. Biol, 115:140.PubMedCrossRefGoogle Scholar
  5. Bischoff, R., 1989a, Analysis of muscle regeneration using single myofibers in culture, Med. Sci. Sports Exer. (In Press).Google Scholar
  6. Bischoff, R., 1989b, Interaction between satellite cells and skeletal muscle fibers, Development (In Press).Google Scholar
  7. Clegg, C. H., Linkhart, T. A., Olwin, B. B., and Hauschka, S. D., 1987, Growth factor control of skeletal muscle differentiation: commitment to terminal differentiation occurs in G1 phase and is repressed by fibroblast growth factor, J. Cell Biol., 105: 949.PubMedCrossRefGoogle Scholar
  8. Darr, K. C. and Schultz, E., 1987, Exercise-induced satellite cell activation in growing and mature skeletal muscle, J. Appl. Physiol., 63: 1816.PubMedGoogle Scholar
  9. DiMario, J., Buffinger, N., Yamada, S., and Strohman, R. C., 1989, Fibroblast growth factor in the extracellular matrix of dystrophic ( MDX) mouse muscle, Science, 244: 688.PubMedCrossRefGoogle Scholar
  10. Florini, J. R. and Ewton, D. Z., 1988, Actions of transforming growth factor-beta on muscle cells, J. Cell. Physiol., 135: 301.PubMedCrossRefGoogle Scholar
  11. Giddings, C. J., Neaves, W. B., and Gonyea, W. J., 1985, Muscle fiber necrosis and regeneration induced by prolonged weight-lifting exercise in the cat, Anat. Rec., 211:133.PubMedCrossRefGoogle Scholar
  12. Gospodarowicz, D., Cheng, J., Lui, G.-M., Baird, A., and Bohlent, P., 1984, Isolation of brain fibroblast growth factor by heparin-Sepharose affinity chromatography: Identity with pituitary fibroblast growth factor, Proc. Nat. Acad. Sci. USA, 81: 6963.PubMedCrossRefGoogle Scholar
  13. Gospodarowicz, D., Weseman, J., and Moran, J., 1975, Presence in brain of a mitogenic agent promoting proliferation of myoblasts in low density culture, Nature, 256: 216.PubMedCrossRefGoogle Scholar
  14. Grounds, M. D. and McGeachie, J. K., 1987, A model of myogenesis in vivo, derived from detailed autoradiographic studies of regenerating skeletal muscle, challenges the concept of quantal mitosis, Cell Tissue Res., 250: 563.PubMedGoogle Scholar
  15. Irintchev, A. and Wernig, A., 1987, Muscle damage and repair in voluntarily running mice: strain and muscle differences, Cell Tissue Res., 249: 509.PubMedCrossRefGoogle Scholar
  16. Jodczyk, K. J., Bankowski, E., and Borys, A., 1986, Stimulatory effect of platelet-breakdown products on muscle regeneration, Zentralbl. Allg. Pathol., 131: 357.PubMedGoogle Scholar
  17. Kardami, E., Spector, D., and Strohman, R. C., 1985, Myogenic growth factor present in skeletal muscle is purified by heparin-affinity chromatography, Proc. Nat. Acad. Sci. USA, 82:8044.PubMedCrossRefGoogle Scholar
  18. McGeachie, J. and Allbrook, D., 1978, Cell proliferation in skeletal muscle following denervation or tenotomy. A series of autoradiographic studies, Cell Tissue Res., 193:259.PubMedCrossRefGoogle Scholar
  19. McGeachie, J. K. and Grounds, M. D., 1987, Initiation and duration of muscle precursor replication after mild and severe injury to skeletal muscle of mice. An autoradiographic study., Cell Tissue Res., 248:125.PubMedCrossRefGoogle Scholar
  20. Ross, J. J., Duxson, M. J., and Harris, A. J., 1987, Formation of primary and secondary myotubes in rat lumbrical muscles, Development, 100:383.PubMedGoogle Scholar
  21. Venkatasubramanian, K. and Solursh, M., 1984, Chemotactic behavior of myoblasts, Dev. Biol., 104:428.PubMedCrossRefGoogle Scholar
  22. Westall, F. C., Lennon, V. A., and Gospodarowicz, D., 1974, Brain-derived fibroblast growth factor: identity with a fragment of the basic protein of myelin, Proc. Natnl. Acad. Sci USA, 75: 4675CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Richard Bischoff
    • 1
  1. 1.Department of Anatomy and NeurobiologyWashington University School of MedicineSt. LouisUSA

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