The DMD Gene Promoter: A Potential Role in Gene Therapy
I have been asked to discuss the work our group in Toronto has been doing in examining the DMD gene promoter region at the molecular level so that we might better understand the factors involved in regulating the transcription of this gene. This topic differs significantly from the previous talks we have just heard on the technical aspects of myoblast transplantation but while it may not be essential to fully understand the in vivo regulation of the DMD gene for the immediate experiments being proposed here, a knowledge of DMD gene regulation may well be necessary if long term therapy is to be successful.
KeywordsBecker Muscular Dystrophy Myoblast Transplantation Duchenne Muscular Dystrophy Gene Gene Core Promoter Myoblast Transfer
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