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The Proliferation and Fusion of Myoblasts In Vivo

  • Miranda D. Grounds
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 280)

Abstract

In this paper the term myoblasts is a general term for all muscle precursor cells. The aim of myoblast therapy is to introduce normal myoblasts into dystrophic (dy) hosts, and to fuse the maximum number of normal donor myoblasts with dy host muscle cells. Some of the questions that need to be discussed are: How many host muscle precursors or areas of regenerating muscle fibres are normally available at any one time to fuse with the implanted myoblasts, and therefore what proportion of the dy muscle fibres will actually incorporate donor muscle nuclei after a single injection of myoblasts? We also need to know whether the introduced myoblasts should be encouraged to proliferate locally or should they just fuse after implantation? For how long can these implanted myoblasts persist without fusing? (This may have immunological implications). Finally, what are the conditions in vivo that regulate or enhance the proliferation or the fusion of myoblasts?

Keywords

Satellite Cell Muscle Regeneration Cell Lineage Model Muscle Precursor Muscle Satellite Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Miranda D. Grounds
    • 1
  1. 1.Department of PathologyUniversity of Western Australia Queen Elizabeth II Medical CentreNedlandsAustralia

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