Practical Aspects of Myoblast Implantation: Investigations on Two Inherited Myopathies in Animals
For some years, our group has been studying the idea of implanting normal muscle precursor cells (mpc) into the skeletal muscles of individuals suffering from inherited myopathies, in an attempt to alleviate the disease. The idea behind this is simple: multinucleated muscle fibres are formed during muscle regeneration by the fusion of mononucleated mpc (Stockdale and Holtzer, 1961); during growth, mpc become incorporated into the muscle fibres (Moss and Leblond, 1971). It follows that if we can implant normal mpc into growing or regenerating myopathic muscle, the implanted mpc would become incorporated into the host muscle fibres (Watt et al. 1982, 1984). The presence of myonuclei of normal origin, carrying the normal genome, within the myopathic fibre should help to alleviate the myopathy.
KeywordsDuchenne Muscular Dystrophy Extensor Digitorum Longus Duchenne Muscular Dystrophy Phosphorylase Kinase Muscle Precursor Cell
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