Medical Virology of Small Round Gastroenteritis Viruses
Despite the medical importance of viral diarrheas, the responsible etiologic agents were totally unknown until the discovery of Norwalk virus in 1972 (Kapikian et al. 1972). The main reason for this delay in their recognition was the inability to cultivate in cell culture etiologic agents from stool specimens. This was in marked contrast to the success in cultivating the many viruses causing respiratory tract disease, measles, mumps and other common viral syndromes. It was only when electron microscopic (EM) and antigen detection techniques were applied to the study of stool specimens that viral gastroenteritis agents were discovered and their medical importance subsequently ascertained.
KeywordsNorwalk Virus Montgomery County Gastroenteritis Outbreak Immune Electron Microscopy Human Caliciviruses
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