A Possible Role for Glycoprotein gpV in the Pathogenesis of Varicella-Zoster Virus
Varicella-zoster virus (VZV) is one of the six known human herpesviruses. It is the causative agent of chicken pox (varicella) as the result of primary infection and shingles (zoster) upon reactivation from the latent state. A number of considerations make it clear that our knowledge of the natural history of this virus must be expanded. First, the increasing age of the general population in the United States is likely to lead to an increase in cases of recrudescent zoster with attendant morbidity. Second, both varicella and zoster can lead to systemic and potentially life-threatening infections in the immunocompromised. Third, a live attenuated VZV vaccine has been used extensively in Japan and is completing clinical trials in the United States (1).
KeywordsVaccinia Virus Vaccine Strain Zoster Patient Vaccinia Virus Expression Human Convalescent Seron
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