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Immunobiology and Prophylaxis of Human Herpesvirus Infections pp 83–91Cite as

A Possible Role for Glycoprotein gpV in the Pathogenesis of Varicella-Zoster Virus

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 278))

Abstract

Varicella-zoster virus (VZV) is one of the six known human herpesviruses. It is the causative agent of chicken pox (varicella) as the result of primary infection and shingles (zoster) upon reactivation from the latent state. A number of considerations make it clear that our knowledge of the natural history of this virus must be expanded. First, the increasing age of the general population in the United States is likely to lead to an increase in cases of recrudescent zoster with attendant morbidity. Second, both varicella and zoster can lead to systemic and potentially life-threatening infections in the immunocompromised. Third, a live attenuated VZV vaccine has been used extensively in Japan and is completing clinical trials in the United States (1).

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References

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Author information

Authors and Affiliations

  1. Departments of Biochemistry, Uniformed Services University of the Health Sciences, Bethesda, Maryland, 20814, USA

    Paul R. Kinchington & William T. Ruyechan

  2. Departments of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, 20814, USA

    Paul Ling, Michael Pensiero & John Hay

  3. Department of Pediatrics, College of Physicians and Surgeons of Columbia University, New York, New York, 10032, USA

    Ann Gershon

Authors
  1. Paul R. Kinchington
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  2. Paul Ling
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  3. Michael Pensiero
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  4. Ann Gershon
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  5. John Hay
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  6. William T. Ruyechan
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Editor information

Editors and Affiliations

  1. Eli Lilly and Company, Indianapolis, Indiana, USA

    Carlos Lopez

  2. Kyushu University, Fukuoka, Japan

    Ryoichi Mori

  3. The University of Chicago, Chicago, Illinois, USA

    Bernard Roizman

  4. University of Alabama at Birmingham, Birmingham, Alabama, USA

    Richard J. Whitley

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© 1990 Plenum Press, New York

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Kinchington, P.R., Ling, P., Pensiero, M., Gershon, A., Hay, J., Ruyechan, W.T. (1990). A Possible Role for Glycoprotein gpV in the Pathogenesis of Varicella-Zoster Virus. In: Lopez, C., Mori, R., Roizman, B., Whitley, R.J. (eds) Immunobiology and Prophylaxis of Human Herpesvirus Infections. Advances in Experimental Medicine and Biology, vol 278. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5853-4_9

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  • DOI: https://doi.org/10.1007/978-1-4684-5853-4_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5855-8

  • Online ISBN: 978-1-4684-5853-4

  • eBook Packages: Springer Book Archive

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