The T-Lymphocyte Response to Varicella-Zoster Viral Proteins

  • Ann M. Arvin
  • Celine M. Koropchak
  • Margaret Sharp
  • Randy Bergen
  • Pamela S. Diaz
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 278)


The importance of cellular immunity in the host’s response to varicella-zoster virus (VZV) is manifested clinically by the severity of varicella in children with congenital or acquired T-cell deficiencies (1). The frequent occurrence of herpes zoster with suppression of cellular immunity implies that such immunity is also required to prevent symptoms due to viral reactivation. When a VZV antigen preparation made from sonicated infected cells was used to stimulate T lymphocytes, the early acquisition of VZV-specific T-cell proliferation was found to correlate with mild primary VZV infection, the absence of VZV cellular immunity was associated with progressive varicella, and diminished VZV T-cell immunity defined periods of susceptibility to recurrent VZV in patients with malignancy (2–5). In contrast, immunoglobulin deficiencies have not been associated with severe primary VZV disease, and VZV IgG antibody titers are not usually low at the onset of herpes zoster.


Herpes Simplex Virus Herpes Zoster Cellular Immunity Vaccinia Recombinant Varicella Vaccine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Ann M. Arvin
    • 1
  • Celine M. Koropchak
    • 1
  • Margaret Sharp
    • 1
  • Randy Bergen
    • 1
  • Pamela S. Diaz
    • 1
  1. 1.Department of Pediatrics, Infectious Diseases DivisionStanford University School of MedicineStanfordUSA

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