Differentiation between the Oka Varicella Vaccine Virus and American Wild-Type Varicella-Zoster Virus (VZV)

  • Lawrence D. Gelb
  • Susan G. Adams
  • Dennis E. Dohner
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 278)


A live attenuated varicella-zoster virus (VZV) vaccine was developed by Takahashi and his colleagues in the early 1970s (1). The vaccine has been designated the Oka strain after the child from whom the virus was isolated. Attenuation was believed to have been induced by serial passage of the original clinical isolate at various temperatures and in different cell lines (1, 2). Numerous studies throughout the world have subsequently shown the vaccine to be safe, immunogenic, and highly protective in both healthy and immunosuppressed individuals (3–6).


Vaccine Strain Restriction Pattern Varicella Vaccine Additional Restriction Site BglI Fragment 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Lawrence D. Gelb
    • 1
    • 2
  • Susan G. Adams
    • 2
  • Dennis E. Dohner
    • 2
  1. 1.Division of Infectious DiseasesWashington University School of MedicineSt. LouisUSA
  2. 2.Cochran Veterans Administration HospitalSt. LouisUSA

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