Abstract
A live attenuated varicella-zoster virus (VZV) vaccine was developed by Takahashi and his colleagues in the early 1970s (1). The vaccine has been designated the Oka strain after the child from whom the virus was isolated. Attenuation was believed to have been induced by serial passage of the original clinical isolate at various temperatures and in different cell lines (1, 2). Numerous studies throughout the world have subsequently shown the vaccine to be safe, immunogenic, and highly protective in both healthy and immunosuppressed individuals (3–6).
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References
Takahashi, M., Otsuka, T., Okuno, Y., Asano, Y., Yazaki, T. & Isomura, S. (1974) Lancet 2, 1288–1290.
Takahashi, M. (1986) Pediatrics 78 (suppl.), 736–741.
Weibel, R. E., Neff, B. J., Kuter, B. J., Guess, H. A., Rothenberger, C. A., Fitzgerald, A. J., Connor, K. A., McLean, A. A., Hilleman, M. R., Buynak, E. B. & Scolnick, E. M. (1984) N. Engl. J. Med 310, 1409–1415.
Gershon, A. A., Steinberg, S. P., LaRussa, P., Ferrara, A., Hammerschlag, M., Gelb, L. & NIAID Varicella Vaccine Study Group (1988) J. Infect. Dis. 158, 132–137.
Gershon, A. A., Steinberg, S. P., Gelb, L., Galasso, G., Borkowsky, W., LaRussa, P., Ferrara, A. & NIAID Varicella Vaccine Collaborative Study Group (1984) JAMA 252, 355–362.
Asano, Y., Nagai, T., Miyata, T., Yazaki, T., Ito, S., Yaminishi, K. & Takahashi, M. (1985) Pediatrics 75, 667–671.
Martin, J. H., Dohner, D. E., Wellinghoff, W. J. & Gelb, L. D. (1982) J. Med Vïrol. 9, 69–76.
Straus, S., Aulakh, H., Ruyechan, W., Hay, J., Casey, T., Vande Woude, G., Owens, J. & Smith, H. (1981) J. Virol. 40, 516–525.
Maniatis, T., Frutsch, E. F. & Sambrook, J. (1982) in Molecular Cloning: A Laboratory Manual, eds. Maniatis, Fritsch & Sambrook (Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.), pp. 89–93, 122–123, 133–134, 252–253, 379–380, 390–391.
Southern, E. (1979) in Methods of Enzymology, ed. Wu, R. ( Academic Press, New York ), pp. 152–176.
Richards, J. C., Hyman, R. W. & Rapp, F. (1979) J. Virol. 32, 812–821.
Ecker, J. R. & Hyman, R. W. (1981) J. Virol. 40, 314–318.
Straus, S. E., Owens, J., Ruyechan, W. T., Takiff, H. E., Casey, T. A., Vande Woude, G. F. & Hay, J. (1982) Proc. Natl. Acad Sci. USA 79, 993–997.
Straus, S. E., Hay, J., Smith, H. & Owens, J. (1983) J. Gen. Virol. 64, 1031–1041.
Casey, T. A., Ruyechan, W. T., Flora, M. N., Reinhold, W., Straus, S. E. & Hay, J. (1985) J. Virol. 54, 639–642.
Hayakawa, Y., Yamamoto, T., Yamanishi, K. & Takahashi, M. (1986) J. Gen. Virol. 67, 1817–1829.
Hondo, R., Yogo, Y., Kurata, T. & Aoyama, Y. (1987) Arch. Virol. 93, 1–12.
Davison, A. J. & Scott, J. E. (1986) J. Gen. Virol. 67, 1759–1816.
Kinoshita, H., Hondo, R., Taguchi, F. & Yogo, Y. (1988) J. Virol. 62, 1097–1100.
Gelb, L. D., Dohner, D. E., Gershon, A. A., Steinberg, S. P., Waner, J. L., Takahashi, M., Dennehy, P. H. & Brown, A. E. (1987) J. Infect. Dis. 155, 633–640.
Ostrove, J. M., Reinhold, W., Fan, C.-M., Zorn, S., Hay, J. & Straus, S. E. (1985) J. ViroL 56, 600–606.
Tsolia, M., Gershon, A. A., Steinberg, S. P., Gelb, L. & NIAID Varicella Vaccine Collaborative Study Group (1990) J. Pediatr. (St. Louis). 116, 184–189.
Hayakawa, Y., Torigoe, S., Shiraki, K., Yamanishi, K. & Takahashi, M. (1984) J. Infect. Dis. 149, 956–963.
Dohner, D. E., Adams, S. G. & Gelb, L. D. (1988) J. Med Virol. 24, 329–341.
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© 1990 Plenum Press, New York
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Gelb, L.D., Adams, S.G., Dohner, D.E. (1990). Differentiation between the Oka Varicella Vaccine Virus and American Wild-Type Varicella-Zoster Virus (VZV). In: Lopez, C., Mori, R., Roizman, B., Whitley, R.J. (eds) Immunobiology and Prophylaxis of Human Herpesvirus Infections. Advances in Experimental Medicine and Biology, vol 278. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5853-4_7
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DOI: https://doi.org/10.1007/978-1-4684-5853-4_7
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