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Differentiation between the Oka Varicella Vaccine Virus and American Wild-Type Varicella-Zoster Virus (VZV)

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Immunobiology and Prophylaxis of Human Herpesvirus Infections

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 278))

Abstract

A live attenuated varicella-zoster virus (VZV) vaccine was developed by Takahashi and his colleagues in the early 1970s (1). The vaccine has been designated the Oka strain after the child from whom the virus was isolated. Attenuation was believed to have been induced by serial passage of the original clinical isolate at various temperatures and in different cell lines (1, 2). Numerous studies throughout the world have subsequently shown the vaccine to be safe, immunogenic, and highly protective in both healthy and immunosuppressed individuals (3–6).

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References

  1. Takahashi, M., Otsuka, T., Okuno, Y., Asano, Y., Yazaki, T. & Isomura, S. (1974) Lancet 2, 1288–1290.

    Article  PubMed  CAS  Google Scholar 

  2. Takahashi, M. (1986) Pediatrics 78 (suppl.), 736–741.

    PubMed  CAS  Google Scholar 

  3. Weibel, R. E., Neff, B. J., Kuter, B. J., Guess, H. A., Rothenberger, C. A., Fitzgerald, A. J., Connor, K. A., McLean, A. A., Hilleman, M. R., Buynak, E. B. & Scolnick, E. M. (1984) N. Engl. J. Med 310, 1409–1415.

    Article  PubMed  CAS  Google Scholar 

  4. Gershon, A. A., Steinberg, S. P., LaRussa, P., Ferrara, A., Hammerschlag, M., Gelb, L. & NIAID Varicella Vaccine Study Group (1988) J. Infect. Dis. 158, 132–137.

    Google Scholar 

  5. Gershon, A. A., Steinberg, S. P., Gelb, L., Galasso, G., Borkowsky, W., LaRussa, P., Ferrara, A. & NIAID Varicella Vaccine Collaborative Study Group (1984) JAMA 252, 355–362.

    Google Scholar 

  6. Asano, Y., Nagai, T., Miyata, T., Yazaki, T., Ito, S., Yaminishi, K. & Takahashi, M. (1985) Pediatrics 75, 667–671.

    PubMed  CAS  Google Scholar 

  7. Martin, J. H., Dohner, D. E., Wellinghoff, W. J. & Gelb, L. D. (1982) J. Med Vïrol. 9, 69–76.

    Article  PubMed  CAS  Google Scholar 

  8. Straus, S., Aulakh, H., Ruyechan, W., Hay, J., Casey, T., Vande Woude, G., Owens, J. & Smith, H. (1981) J. Virol. 40, 516–525.

    PubMed  CAS  Google Scholar 

  9. Maniatis, T., Frutsch, E. F. & Sambrook, J. (1982) in Molecular Cloning: A Laboratory Manual, eds. Maniatis, Fritsch & Sambrook (Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.), pp. 89–93, 122–123, 133–134, 252–253, 379–380, 390–391.

    Google Scholar 

  10. Southern, E. (1979) in Methods of Enzymology, ed. Wu, R. ( Academic Press, New York ), pp. 152–176.

    Google Scholar 

  11. Richards, J. C., Hyman, R. W. & Rapp, F. (1979) J. Virol. 32, 812–821.

    PubMed  CAS  Google Scholar 

  12. Ecker, J. R. & Hyman, R. W. (1981) J. Virol. 40, 314–318.

    PubMed  CAS  Google Scholar 

  13. Straus, S. E., Owens, J., Ruyechan, W. T., Takiff, H. E., Casey, T. A., Vande Woude, G. F. & Hay, J. (1982) Proc. Natl. Acad Sci. USA 79, 993–997.

    Article  PubMed  CAS  Google Scholar 

  14. Straus, S. E., Hay, J., Smith, H. & Owens, J. (1983) J. Gen. Virol. 64, 1031–1041.

    Article  PubMed  CAS  Google Scholar 

  15. Casey, T. A., Ruyechan, W. T., Flora, M. N., Reinhold, W., Straus, S. E. & Hay, J. (1985) J. Virol. 54, 639–642.

    PubMed  CAS  Google Scholar 

  16. Hayakawa, Y., Yamamoto, T., Yamanishi, K. & Takahashi, M. (1986) J. Gen. Virol. 67, 1817–1829.

    Article  PubMed  CAS  Google Scholar 

  17. Hondo, R., Yogo, Y., Kurata, T. & Aoyama, Y. (1987) Arch. Virol. 93, 1–12.

    Article  PubMed  CAS  Google Scholar 

  18. Davison, A. J. & Scott, J. E. (1986) J. Gen. Virol. 67, 1759–1816.

    Article  PubMed  CAS  Google Scholar 

  19. Kinoshita, H., Hondo, R., Taguchi, F. & Yogo, Y. (1988) J. Virol. 62, 1097–1100.

    PubMed  CAS  Google Scholar 

  20. Gelb, L. D., Dohner, D. E., Gershon, A. A., Steinberg, S. P., Waner, J. L., Takahashi, M., Dennehy, P. H. & Brown, A. E. (1987) J. Infect. Dis. 155, 633–640.

    Article  PubMed  CAS  Google Scholar 

  21. Ostrove, J. M., Reinhold, W., Fan, C.-M., Zorn, S., Hay, J. & Straus, S. E. (1985) J. ViroL 56, 600–606.

    PubMed  CAS  Google Scholar 

  22. Tsolia, M., Gershon, A. A., Steinberg, S. P., Gelb, L. & NIAID Varicella Vaccine Collaborative Study Group (1990) J. Pediatr. (St. Louis). 116, 184–189.

    Google Scholar 

  23. Hayakawa, Y., Torigoe, S., Shiraki, K., Yamanishi, K. & Takahashi, M. (1984) J. Infect. Dis. 149, 956–963.

    Article  PubMed  CAS  Google Scholar 

  24. Dohner, D. E., Adams, S. G. & Gelb, L. D. (1988) J. Med Virol. 24, 329–341.

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri, 63110, USA

    Lawrence D. Gelb

  2. Cochran Veterans Administration Hospital, St. Louis, Missouri, 63106, USA

    Lawrence D. Gelb, Susan G. Adams & Dennis E. Dohner

Authors
  1. Lawrence D. Gelb
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  2. Susan G. Adams
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  3. Dennis E. Dohner
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Editor information

Editors and Affiliations

  1. Eli Lilly and Company, Indianapolis, Indiana, USA

    Carlos Lopez

  2. Kyushu University, Fukuoka, Japan

    Ryoichi Mori

  3. The University of Chicago, Chicago, Illinois, USA

    Bernard Roizman

  4. University of Alabama at Birmingham, Birmingham, Alabama, USA

    Richard J. Whitley

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© 1990 Plenum Press, New York

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Gelb, L.D., Adams, S.G., Dohner, D.E. (1990). Differentiation between the Oka Varicella Vaccine Virus and American Wild-Type Varicella-Zoster Virus (VZV). In: Lopez, C., Mori, R., Roizman, B., Whitley, R.J. (eds) Immunobiology and Prophylaxis of Human Herpesvirus Infections. Advances in Experimental Medicine and Biology, vol 278. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5853-4_7

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  • DOI: https://doi.org/10.1007/978-1-4684-5853-4_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5855-8

  • Online ISBN: 978-1-4684-5853-4

  • eBook Packages: Springer Book Archive

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