Advertisement

Viral Pathology of Human Herpesvirus 6 Infection

  • T. Kurata
  • T. Iwasaki
  • T. Sata
  • T. Wakabayashi
  • K. Yamaguchi
  • T. Okuno
  • K. Yamanishi
  • Y. Takei
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 278)

Abstract

Since the first isolation of a new human herpesvirus (1), now referred to as human herpesvirus 6 (HHV-6) at the suggestion of Lusso et al. (2), several groups have been able independently to isolate the virus from patients with lymphoproliferative disorder and human immunodeficiency virus (HIV) infection and from normal adults (3–5). Recently, Yamanishi et al. (6) discovered that HHV-6 is a causal agent of exanthem subitum. Almost all children show seroconversion to HHV-6 from 5 mo by the time they are 2 yr old (7). Molecular characterization indicates antigenic distinction between HHV-6 and other human herpesviruses, human cytomegalovirus (CMV), herpes simplex types 1 and 2 (HSV-1 and HSV-2), varicella-zoster virus (VZV), and Epstein-Barr virus (EBV) (1, 5). Tropism analysis using cord-blood lymphocytes has suggested that HHV-6, in addition to being the causal agent of exanthem subitum, causes a predominant CD4 mature T-lymphocyte tropism, but that has not been clarified yet (table 1). In this article we describe HHV-6-related pathological findings obtained by immunohistochemical methods.

Keywords

Human Immunodeficiency Virus Human Immunodeficiency Virus Infection Herpes Simplex Type Foamy Histiocyte Malignant Thymoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Salahuddin, S. Z., Ablashi, D. V., Markham, P. D., Josephs, S. F., Sturzenegger, S., Kaplan, M., Halligna, G., Biberfeld, P., Wong-Staal, F., Kramarsky, B. and Gallo, R. C. (1986) Science (Washington, D.C., 1883-) 234, 596–601.CrossRefGoogle Scholar
  2. 2.
    Lusso, P., Sallahuddin, S. Z., Ablashi, D. V., Gallo, R. C., Veronese, F. D. and Markham, P. D. (1987) Lancet 2, 743–744.PubMedCrossRefGoogle Scholar
  3. 3.
    Downing, R. G., Sewankambo, N., Serwadda, D., Honess, R., Crawford, D., Jarrett, R. and Griffin, B. E. (1987) Lancet 2, 390.PubMedCrossRefGoogle Scholar
  4. 4.
    Tedder, R. S., Briggs, M., Cameron, C. H., Honess, R., Robertson, D. and Whittle, H. (1987) Lancet 2, 390–392.PubMedCrossRefGoogle Scholar
  5. 5.
    Lopez, C., Pellet, P., Stewart, J., Goldsmith, C., Sanderlin, K., Black, J., Warfield, D. and Feolino, P. (1988) J. Infect. Dis. 157, 1271–1273.PubMedCrossRefGoogle Scholar
  6. 6.
    Yamanishi, K., Okuno, T., Shiraki, K., Takahashi, M., Kondo, T., Asano, Y. and Kurata, T. (1988) Lancet 1, 1065–1067.PubMedCrossRefGoogle Scholar
  7. 7.
    Brown, N. A., Sumaya, C. V., Liu, C. R., Ench, Y., Kovacs, A., Coronesi, M. and Kaplan, M. H. (1988) Lancet 2, 396.PubMedCrossRefGoogle Scholar
  8. 8.
    Takahashi, K., Sonoda, S., Higashi, K., Kondo, T., Takahashi, H., Takahashi, M. and Yamanishi, K. (1989) J. Virol. 63, 3161–3163.PubMedGoogle Scholar
  9. 9.
    Kurata, T., Hondo, R., Sato, S., Oda, A., Aoyama, Y. and McCormick, J. B. (1983) Ann. N.Y. AcacL Sci. 420, 192–207.CrossRefGoogle Scholar
  10. 10.
    Sata, T., Kurata, R., Aoyama, Y., Sakaguchi, M., Yamanouchi, K. and Takeda, K. (1986) Virchows Arch. A 410, 133–138.CrossRefGoogle Scholar
  11. 11.
    Kikuchi, M. (1972) Nippon Ketsueki Gakkai Zasshi 35, 379–380 (in Japanese).Google Scholar
  12. 12.
    Fujimoto, Y., Kozime, Y. and Yamaguchi, K. (1972) Naika 20, 920–927 (in Japanese).Google Scholar
  13. 13.
    Dorfman, R. F. (1987) Arch. Pathol. Lab. MecL 111, 1026–1029.Google Scholar
  14. 14.
    Niderman, J. C., Liu, C. R., Kaplan, M. H. and Brown, N. A. (1988) Lancet 2, 817–819.CrossRefGoogle Scholar
  15. 15.
    Kirchesch, H., Mertens, T., Burkhardt, U., Kruppenbacher, J. P., Hoffken, A. and Eggers, H. J. (1988) Lancet 2, 273–274.PubMedCrossRefGoogle Scholar
  16. 15.
    Kirchesch, H., Mertens, T., Burkhardt, U., Kruppenbacher, J. P., Hoffken, A. and Eggers, H. J. (1988) Lancet 2, 273–274.PubMedCrossRefGoogle Scholar
  17. 17.
    Ward, J. M., O’Keary, T. J., Baskin, G. B., Benveniste, R., Harris, C. A., Nara, P. L. and Rhodes, R. H. (1987) Am. J. Pathol. 127, 199–205.PubMedGoogle Scholar
  18. 18.
    Baronic, C. D., Pezzella, F., Pezzella, M., Macchi, B., Vitolo, D., Uccini, S. and Ruco, L. (1988) Am. J. Pathol 133, 498–506.Google Scholar
  19. 19.
    Vazeux, R., Brousse, N., Jarry, A., Henin, D., Marche, C., Vedrenne, C., Mikol, J., Wolff, M., Michon, C., Rosenbaum, W., Bureau, J. F., Montagnier, L. and Brahic, M. (1987) Am. J. Pathol 126, 403–410.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • T. Kurata
    • 1
  • T. Iwasaki
    • 1
  • T. Sata
    • 1
  • T. Wakabayashi
    • 2
  • K. Yamaguchi
    • 3
  • T. Okuno
    • 4
  • K. Yamanishi
    • 4
  • Y. Takei
    • 5
  1. 1.Department of PathologyNational Institute of HealthTokyo 141Japan
  2. 2.Department of Clinical Pathology, Institute of Medical ScienceUniversity of TokyoTokyo 108Japan
  3. 3.Department of PathologyKanto Teishin HospitalTokyo 141Japan
  4. 4.Department of Virology, Institute of Microbial DiseasesOsaka UniversityOsaka 565Japan
  5. 5.Department of NeuropathologyEmory University School of MedicineAtlantaUSA

Personalised recommendations