Abstract
Since the first isolation of a new human herpesvirus (1), now referred to as human herpesvirus 6 (HHV-6) at the suggestion of Lusso et al. (2), several groups have been able independently to isolate the virus from patients with lymphoproliferative disorder and human immunodeficiency virus (HIV) infection and from normal adults (3–5). Recently, Yamanishi et al. (6) discovered that HHV-6 is a causal agent of exanthem subitum. Almost all children show seroconversion to HHV-6 from 5 mo by the time they are 2 yr old (7). Molecular characterization indicates antigenic distinction between HHV-6 and other human herpesviruses, human cytomegalovirus (CMV), herpes simplex types 1 and 2 (HSV-1 and HSV-2), varicella-zoster virus (VZV), and Epstein-Barr virus (EBV) (1, 5). Tropism analysis using cord-blood lymphocytes has suggested that HHV-6, in addition to being the causal agent of exanthem subitum, causes a predominant CD4 mature T-lymphocyte tropism, but that has not been clarified yet (table 1). In this article we describe HHV-6-related pathological findings obtained by immunohistochemical methods.
Keywords
- Human Immunodeficiency Virus
- Human Immunodeficiency Virus Infection
- Herpes Simplex Type
- Foamy Histiocyte
- Malignant Thymoma
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Salahuddin, S. Z., Ablashi, D. V., Markham, P. D., Josephs, S. F., Sturzenegger, S., Kaplan, M., Halligna, G., Biberfeld, P., Wong-Staal, F., Kramarsky, B. and Gallo, R. C. (1986) Science (Washington, D.C., 1883-) 234, 596–601.
Lusso, P., Sallahuddin, S. Z., Ablashi, D. V., Gallo, R. C., Veronese, F. D. and Markham, P. D. (1987) Lancet 2, 743–744.
Downing, R. G., Sewankambo, N., Serwadda, D., Honess, R., Crawford, D., Jarrett, R. and Griffin, B. E. (1987) Lancet 2, 390.
Tedder, R. S., Briggs, M., Cameron, C. H., Honess, R., Robertson, D. and Whittle, H. (1987) Lancet 2, 390–392.
Lopez, C., Pellet, P., Stewart, J., Goldsmith, C., Sanderlin, K., Black, J., Warfield, D. and Feolino, P. (1988) J. Infect. Dis. 157, 1271–1273.
Yamanishi, K., Okuno, T., Shiraki, K., Takahashi, M., Kondo, T., Asano, Y. and Kurata, T. (1988) Lancet 1, 1065–1067.
Brown, N. A., Sumaya, C. V., Liu, C. R., Ench, Y., Kovacs, A., Coronesi, M. and Kaplan, M. H. (1988) Lancet 2, 396.
Takahashi, K., Sonoda, S., Higashi, K., Kondo, T., Takahashi, H., Takahashi, M. and Yamanishi, K. (1989) J. Virol. 63, 3161–3163.
Kurata, T., Hondo, R., Sato, S., Oda, A., Aoyama, Y. and McCormick, J. B. (1983) Ann. N.Y. AcacL Sci. 420, 192–207.
Sata, T., Kurata, R., Aoyama, Y., Sakaguchi, M., Yamanouchi, K. and Takeda, K. (1986) Virchows Arch. A 410, 133–138.
Kikuchi, M. (1972) Nippon Ketsueki Gakkai Zasshi 35, 379–380 (in Japanese).
Fujimoto, Y., Kozime, Y. and Yamaguchi, K. (1972) Naika 20, 920–927 (in Japanese).
Dorfman, R. F. (1987) Arch. Pathol. Lab. MecL 111, 1026–1029.
Niderman, J. C., Liu, C. R., Kaplan, M. H. and Brown, N. A. (1988) Lancet 2, 817–819.
Kirchesch, H., Mertens, T., Burkhardt, U., Kruppenbacher, J. P., Hoffken, A. and Eggers, H. J. (1988) Lancet 2, 273–274.
Kirchesch, H., Mertens, T., Burkhardt, U., Kruppenbacher, J. P., Hoffken, A. and Eggers, H. J. (1988) Lancet 2, 273–274.
Ward, J. M., O’Keary, T. J., Baskin, G. B., Benveniste, R., Harris, C. A., Nara, P. L. and Rhodes, R. H. (1987) Am. J. Pathol. 127, 199–205.
Baronic, C. D., Pezzella, F., Pezzella, M., Macchi, B., Vitolo, D., Uccini, S. and Ruco, L. (1988) Am. J. Pathol 133, 498–506.
Vazeux, R., Brousse, N., Jarry, A., Henin, D., Marche, C., Vedrenne, C., Mikol, J., Wolff, M., Michon, C., Rosenbaum, W., Bureau, J. F., Montagnier, L. and Brahic, M. (1987) Am. J. Pathol 126, 403–410.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Plenum Press, New York
About this chapter
Cite this chapter
Kurata, T. et al. (1990). Viral Pathology of Human Herpesvirus 6 Infection. In: Lopez, C., Mori, R., Roizman, B., Whitley, R.J. (eds) Immunobiology and Prophylaxis of Human Herpesvirus Infections. Advances in Experimental Medicine and Biology, vol 278. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5853-4_5
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5853-4_5
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5855-8
Online ISBN: 978-1-4684-5853-4
eBook Packages: Springer Book Archive