Brovavir: Its Antiherpesviral Activity and Mode of Action
Since the discovery of acyclovir, many compounds have been proposed as candidates for a new antiherpesviral agent for clinical use. They are acyclic guanosine analogues, 5-substituted deoxypyrimidine derivatives, and 2’-fluoroarabinosylpyrimidine nucleosides. However, only ganciclovir has been approved for clinical use. The reasons the others have not been developed as new agents are thought to be that (i) they are not as potent as acyclovir, (ii) their antiviral spectrum is similar to that of acyclovir, and (iii) their toxicity is not as low as that of acyclovir.
KeywordsThymidine Kinase Cutaneous Infection Simian Varicella Virus Potent Antiviral Activity Immunosuppressed Mouse
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