Brovavir: Its Antiherpesviral Activity and Mode of Action

  • Haruhiko Machida
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 278)


Since the discovery of acyclovir, many compounds have been proposed as candidates for a new antiherpesviral agent for clinical use. They are acyclic guanosine analogues, 5-substituted deoxypyrimidine derivatives, and 2’-fluoroarabinosylpyrimidine nucleosides. However, only ganciclovir has been approved for clinical use. The reasons the others have not been developed as new agents are thought to be that (i) they are not as potent as acyclovir, (ii) their antiviral spectrum is similar to that of acyclovir, and (iii) their toxicity is not as low as that of acyclovir.


Thymidine Kinase Cutaneous Infection Simian Varicella Virus Potent Antiviral Activity Immunosuppressed Mouse 
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  1. 1.
    Machida, H., Sakata, S., Kuninaka, A., Yoshino, H., Nakayama, C.and Saneyoshi, M. (1979) Antimicrob. Agents Chemother. 16, 158–163.PubMedGoogle Scholar
  2. 2.
    Machida, H., Kuninaka, A., Yoshino, H., Ikeda, K.and Mizuno, Y. (1980) Antimicrob. Agents Chemother. 17, 1030–1031.PubMedGoogle Scholar
  3. 3.
    Sakata, S., Shibuya, S., Machida, H., Yoshino, H., Hirota, K., Senda, S., Ikeda, K.and Mizuno, Y. (1980) Nucleic Acids Res. Symp. Ser. 8, S39 - S42.Google Scholar
  4. 4.
    Machida, H., Sakata, S., Kuninaka, A.and Yoshino, H. (1981) Antimicrob. Agents Chemother. 20, 47–52.PubMedGoogle Scholar
  5. 5.
    Machida, H., Kuninaka, A.and Yoshino, H. (1982) Antimicrob. Agents Chemother. 21, 358–361.PubMedGoogle Scholar
  6. 6.
    Machida, H.and Takezawa, T. (1990) Antimicrob. Agents Chemother. 34 no. 5.Google Scholar
  7. 7.
    Nagafuchi, S., Oda, H., Mori, R.and Taniguchi, T. (1979) J. Gen. Virol. 44, 715–723.PubMedCrossRefGoogle Scholar
  8. 8.
    Kumagai, M., Sakata, S., Yamaguchi, T., Ikeda, K.and Machida, H. (1989) J. Labelled Compd. Radiopharm. 27, 503–507.CrossRefGoogle Scholar
  9. 9.
    Suzutani, T., Machida, H., Sakuma, T.and Azuma, M. (1988) Antimicrob. Agents Chemother. 32, 1547–1551.PubMedGoogle Scholar
  10. 10.
    Yokota, T., Konno, K., Mori, S., Shigeta, S., Kumagai, M., Watanabe, Y.and Machida, H. (1989) Mol. PharmacoL 36, 312–316.PubMedGoogle Scholar
  11. 11.
    Machida, H. (1986) Antimicrob. Agents Chemother. 29, 524–526.PubMedGoogle Scholar
  12. 12.
    Machida, H. (1986) Biken J. 29, 1–6.PubMedGoogle Scholar
  13. 13.
    Lin, J.-C.and Machida, H. (1988) Antimicrob. Agents Chemother. 32, 1068–1072.PubMedGoogle Scholar
  14. 14.
    Machida, H., Sakata, S.and Saito, K. (1985) in Herpes Viruses and Virus Chemotherapy, ed. Kono, R.and Nakajima, A. ( Excerpta Medica, Amsterdam ), pp. 63–66.Google Scholar
  15. 15.
    Cheng, Y.-C., Dutschman, G., Fox, J. J., Watanabe, K. A.and Machida, H. (1981) Antimicrob. Agents Chemother. 20, 420–423.PubMedGoogle Scholar
  16. 16.
    Ruth, J. L.and Cheng, Y.-C. (1981) Mol. PharmacoL 20, 415–422.PubMedGoogle Scholar
  17. 17.
    Descamps, J., Sehgal, R. K., De Clercq, E.and Allaudeen, H. S. (1982) J. Virol. 43, 332–336.PubMedGoogle Scholar
  18. 18.
    Shigeta, S., Yokota, T., Iwabuchi, T., Baba, M., Konno, K., Ogata, M.and De Clercq, E. (1983) J. Infect. Dis. 147, 576–584.PubMedCrossRefGoogle Scholar
  19. 19.
    Suzutani, T., Machida, H.and Sakuma, T. (1988)Antimicrob. Agents Chemother. 32, 1046–1052.Google Scholar
  20. 20.
    Machida, H.and Sakata, S. (1984) Antiviral Res. 4, 135–141.PubMedCrossRefGoogle Scholar
  21. 21.
    Reefschläger, J., Wutzler, P., Thiel. K.-D.and Herrmann, G. (1986) Antiviral Res. 6, 83–93.PubMedCrossRefGoogle Scholar
  22. 22.
    Kern, E. R., Richards, J. T.and Overall, J. C., Jr. (1986) Antiviral Res. 6, 189–195.Google Scholar
  23. 23.
    Park, N.-H., Pavan-Langston, D., McLean, S. L.and Albert, D. M. (1979) Antimicrob. Agents Chemother. 15, 775–779.PubMedGoogle Scholar
  24. 24.
    Fyfe, J. A. (1982) MoL PharmacoL 21, 432–437.PubMedGoogle Scholar
  25. 25.
    Ayisi, N. K., Wall, R. A., Wanklin, R. J., Machida, H., De Clercq, E.and Sacks, S. L. (1987) Mol. PharmacoL 31, 422–429.PubMedGoogle Scholar
  26. 26.
    Soike, K. F., Baskin, G., Cantrell, C.and Gerone, P. (1984) Antiviral Res. 4, 245–257.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Haruhiko Machida
    • 1
  1. 1.Biology Laboratory, Research and Development DivisionYamasa Shoyu Company, LimitedChoshi-shi 288Japan

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