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Acyclovir: The Past Ten Years

  • Richard J. Whitley
  • Mark Middlebrooks
  • John W. GnannJr.
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 278)

Abstract

Compared to the remarkable progress made in the treatment of bacterial infections over the past four decades, advances in the chemotherapy of viral diseases have proceeded at a much slower pace. In the United States, only a few antiviral agents of proven clinical value are currently available for a limited number of indications. Initial success was achieved with vidarabine therapy of severe and life-threatening herpes simplex virus (HSV) infections—specifically, herpes simplex encephalitis (HSE) and neonatal HSV infections. Subsequently, acyclovir has become the standard therapeutic agent for life-threatening HSV and varicella-zoster virus (VZV) infections in both normal and immunocompromised hosts. The success of this compound has been nothing short of remarkable. Nevertheless, the recent problems encountered with viral resistance to acyclovir in severely immunocompromised patients with human immunodeficiency virus infection demonstrates the necessity for the development of newer antiviral agents that are active against HSVs. This article will review the advances made over the past decade in the management of HSV and VZV infections with acyclovir.

Keywords

Herpes Simplex Virus Chronic Fatigue Syndrome Herpes Zoster Thymidine Kinase Postherpetic Neuralgia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Schaeffer, H. J., Beauchamp, L., deMiranda, P., Elion, G. B., Baver, D. J. and Collins, P. (1978) Nature (London) 272, 583–585.CrossRefGoogle Scholar
  2. 2.
    Elion, G. B., Furman, P. A., Fyre, J. A., de Miranda, P., Beaucham, P. L. and Schaeffner, H. (1977) Proc. NatL Acad. Sci. USA 74, 5716–5720.Google Scholar
  3. 3.
    Gnann, J. W., Jr., Barton, N. H. and Whitley, R. J. (1983) Pharmacotherapy (Carlisle, Mass.) 3, 275–283.Google Scholar
  4. 4.
    Whitley, R. J., Spruance, S., Hayden, F. G., Overall, J., Alford, C. A., Jr., Gwaltney, J. M., Jr., Soong, S. J. and NIAID Collaborative Antiviral Study Group (1984) J. Infect. Dis. 149, 1–8.CrossRefGoogle Scholar
  5. 5.
    Mitchell, C. D., Bean, B., Gentry, S. R., Groth, K. E., Boen, J. R. and Balfour, H. H., Jr. (1981) Lancet 1, 1389–1392.Google Scholar
  6. 6.
    Holland, H. K., Wingard, J. R. and Saral, R. (in press) Cancer Invest.Google Scholar
  7. 7.
    Wade, J. C., Newton, B., McLaren, C., Flournoy, N., Keeney, R. E. and Meyers, J. D. (1982) Ann. Intern. Med 96, 265–269.PubMedGoogle Scholar
  8. 8.
    Meyers, J. D., Wade, J. C., Mitchell, C. D., Saral, R., Lietman, P. S., Durack, D. T., Levin, M. J., Segreti, A. C. and Balfour, H. H., Jr. (1982) Am. J. Med 73A, 229–235.PubMedCrossRefGoogle Scholar
  9. 9.
    Shepp, D. H., Newton, B. A., Dandliker, P. S., Flourney, N. and Meyers, J. D. (1985) Ann. Intern. Med. 102, 783–785.PubMedGoogle Scholar
  10. 10.
    Saral, R., Burns, W. H., Laskin, O. L., Santos, G. W. and Leitman, A. S. (1981) N. Engt J. Med 305, 63–67.CrossRefGoogle Scholar
  11. 11.
    Hann, I. M., Prentice, H. G., Blacklock, H. A., Ross, M. G., Brigden, D., Rosling, A. E., Burke, C., Crawford, D. H., Brumfitt, W. and Hoffbrand, A. V. (1983) Br. Med J. 287, 348–388.CrossRefGoogle Scholar
  12. 12.
    Sarai, R., Ambinder, R. F., Burns, W. H., Angelopulos, C. M., Griffin, D. E., Burke, P. J. and Lietman, P. S. (1983) Ann. Intern. Med 99, 773–776.Google Scholar
  13. Wade, J. C., Newton, B., Meyers, J. P. and Flournoy, N. (1984)Ann. Intern. Med 100, 823–828.Google Scholar
  14. 14.
    Shepp, D. H., Dandliker, P. S., Meyers, J. E. and Flournoy, N. (1987) Transplantation 43, 654–658.PubMedCrossRefGoogle Scholar
  15. 15.
    Corey, L., Nahmias, A. J., Guinan, M. E., Benedetti, J. K., Critchlow, C. M and Holmes, K. K. (1982) N. EngL J. Med 306, 1313–1319.PubMedCrossRefGoogle Scholar
  16. 16.
    Bryson, Y. J., Dillon, M., Lovett, M., Acuna, G., Taylor, S., Cherry, J., Johnson, L., Wiesmeier, E., Growdon, W., Creagh-Kirk, T. and Keeney, R. (1983) N. EngL J. Med 308, 916–920.PubMedCrossRefGoogle Scholar
  17. 17.
    Corey, L., Fife, K. H., Benedetti, J. K., Winter, C. A., Fahnlander, A., Connor, J. D., Hintz, M. A., Holmes, K. K. (1983) Ann. Intern. Med 98, 914–921.PubMedGoogle Scholar
  18. 18.
    Peacock, J. E., Kaplowitz, L. G., Sparling, P. F., Durack, D. T., Gnann, J. W., Whitley, R. J., Lovett, M., Bryson, Y. J., Klein, R. J., Friedman-Kien, A. E., Knowlton, G. M. and Davis, L. G. (1988) Am. J. Med 85, 301–306.PubMedCrossRefGoogle Scholar
  19. 19.
    Luby, J. P., Gnann, J. W., Jr., Alexander, W. J., Luby, J. P., Gann, J. W., Jr., Alexander, W. J., Hatcher, V. A., Friedmankien, A. E., Klein, R. J., Keyserling, H., Nahmias, A., Mills, J., Schachter, J., Douglas, J. M., Corey, L. and Sacks, S. L. (1984) J. Infect. Dis. 150, 1–6.PubMedCrossRefGoogle Scholar
  20. 20.
    Reichman, R. C., Badger, G. J., Mertz, G. J., Corey, L., Reichman, R. C., Badger, G. J., Mertz, G. J., Corey, L., Richman, D. D., Connor, J. D., Redfield, D., Savoia, M. C., Oxman, M. N., Bryson, Y., Tyrrell, D. L., Portnoy, J., Creigh-Kirk, T., Keeney, R. E., Ashikaga, T. and Dolin, R. (1984) JAMA 251, 2103–2107.PubMedCrossRefGoogle Scholar
  21. 21.
    Straus, S. E., Takiff, H. E., Seidlin, M., Bachrach, S., Straus, S. E., Takiff, H. E., Seidlin, M., Bachrach, S., Lininger, L., Digiovanna, J. J., Western, K. A., Smith, H. A., Lehrman, S. N., Creigh-Kirk, T. and Ailing, D. W. (1984) N. Engl. J. Med 310, 1545–1550.PubMedCrossRefGoogle Scholar
  22. 22.
    Douglas, J. M., Critchlow, C., Benedetti, J., Mertz, G. J., Connor, J. D., Hintz, M. A., Fahnlander, A., Remington, M., Winter, C. and Corey, L. (1984) N. Engl. J. Med 310, 1551–1556.PubMedCrossRefGoogle Scholar
  23. 23.
    Mertz, G. J., Eron, L., Kaurman, R., Goldberg, L., Raab, B., Conant, M., Mills, J., Kurtz, T. and Davis, G. L. (1988) Am. J. Med 85, 14–19.PubMedGoogle Scholar
  24. 24.
    Mertz, G. J., Jones, C. C., Mills, J., Lemon, S. M., Fife, K. H., Stapleton, J. T., Hill, E. L. and Davis, L. G. (1988) JAMA 260, 201–206.PubMedCrossRefGoogle Scholar
  25. 25.
    Straus, S. (1989) personal communication. 252 R. J. Whitley, M. Middlebrooks, and J. W. Gnann, Jr.Google Scholar
  26. 26.
    Fiddian, P. A., Yeo, J. M., Stubbings, R. and Dean, D. (1983) Br. Med J. 286, 1699–1701.CrossRefGoogle Scholar
  27. Raborn, G. W., McGaw, W. T., Grace, M. and Percy, J. (1988)Am. J. Med 85, 39–42.Google Scholar
  28. 28.
    Gibson, J. R., Klaber, M. R., Harvey, S. G., Tosti, A., Jones, D. and Yeo, J. M. (1986) Dermatologica 172, 104–107.PubMedCrossRefGoogle Scholar
  29. 29.
    Meyrick, R. H., Dodd, H. J., Yeo, J. M. and Kirby, J. D. T. (1985) Br. J. Dermatol. 113, 731–735.CrossRefGoogle Scholar
  30. 30.
    Spruance, S. L. (1988) Am. J. Med 85, 43–45.PubMedGoogle Scholar
  31. 31.
    Whitley, R. J., Alford, C. A., Jr., Hirsch, M. S., Schooley, R. T., Luby, J. P., Aoki, F. Y., Hanley, D., Nahmias, A. J. and NIAID Collaborative Antiviral Study Group (1986) N Engl. J. Med 314, 144–149.CrossRefGoogle Scholar
  32. 32.
    Whitley, R. J., Arvin, A., Prober, C., Corey, L., Powell, D., Plotkin, S., Starr, S., Alford, C., Connor, J., Jacobs, R., Nahmias, A. J., Soong, S. J. and NIAID Collaborative Antiviral Study Group (submitted).Google Scholar
  33. 33.
    Sherry, M. K., Klainer, A. S., Wolff, M. and Gerhard, H. (1988) Ann. Intern. Med 109, 229–232.PubMedGoogle Scholar
  34. 34.
    Laibson, P. R., Pavan-Langston, D., Yeakley, W. R. and Lass, J. (1982) Am. J. Med 73, 281–285.PubMedCrossRefGoogle Scholar
  35. 35.
    Collum, L. M. T., Logan, P., Hillary, I. B. and Ravenscroft, T. (1982) Am. J. Med 73, 290–293.PubMedCrossRefGoogle Scholar
  36. 36.
    Niimuro, M. and Nishikawa, T. (1988) Am. J. Med 85, 49–52.CrossRefGoogle Scholar
  37. 37.
    Laskin, O. L. (1985) Ann. Intern. Med 102, 494–495.PubMedGoogle Scholar
  38. 38.
    Biron, K. and Elion, G. B. (1981) Am. J. Med 73, 54–56.CrossRefGoogle Scholar
  39. Prober, C. G., Kirk, E. L. and Keeney, R. E. (1982) J. Pediatr. (St. Louis) 101, 622–625.Google Scholar
  40. Vilde, J. L., Bricaire, F., Leport, C., Renaudie, M. and Brun-Vezinet, F. (19860) J. Med Virol. 20, 127–134.Google Scholar
  41. 41.
    Balfour, H. H. (1989) personal communication.Google Scholar
  42. 42.
    Al-Nakib, W., Al-Kandari, S., El-Khalik, D. M. A. and El-Shirbiny, A. M. (1983) J. Infect. 6, 4956.CrossRefGoogle Scholar
  43. 43.
    Schlossberg, D. and Littman, M. (1988) Arch. Intern. Med 148, 1630–1632.PubMedCrossRefGoogle Scholar
  44. 44.
    Eder, S. E., Apuzzio, J. J. and Weiss, G. (1988) Am. J. Perinatology 5, 16–18.CrossRefGoogle Scholar
  45. 45.
    Balfour, H. H., Bean, B., Laskin, O. L., Ambinder, R. F., Meyers, J. D., Wade, J. C., Zaia, J. A., Aeppli, D., Kirk, E. L., Segreti, A. C., Keeney, R. and Burroughs Wellcome Collaborative Acyclovir Study Group (1983) N. Engl. J. Med 308, 1448–1453.CrossRefGoogle Scholar
  46. 46.
    Shepp, D. H., Dandliker, P. S. and Meyers, J. D. (1986) N. Engl. J. Med 314, 208–212.PubMedCrossRefGoogle Scholar
  47. 47.
    Lundgren, G., Wilczek, H., Lonnqvist, B., Lindholm, A., Wahren, B. and Ringden, O. (1985) Scand J. Infect. Dir. Suppl. 47, 137–144.Google Scholar
  48. 48.
    Perren, T. J., Powles, R. L., Easton, D., Stole, K. and Selby, P. J. (1988) Am. J. Med 85, 99–101.PubMedGoogle Scholar
  49. 49.
    Peterslund, N. A., Ipsen, J., Schonheyder, H., Seyer-Hansen, K., Esmann, V. and Juhl, H. (1981) Lancet 2, 827–830.PubMedCrossRefGoogle Scholar
  50. 50.
    Bean, B., Braun, C. and Balfour, H. (1982) Lancet 2, 118–121.PubMedCrossRefGoogle Scholar
  51. 51.
    McGill, J., MacDonald, D. R., Fall, C., McKendrick, G. D. W. and Copplestone, A. (1983) J. Infect. Dis. 6, 157–161.Google Scholar
  52. 52.
    Wood, M. J., Ogan, P. H., McKendrick, M. W., Care, C. D., McGill, J. I. and Webb, E. M. (1988) Am. J. Med 85, 79–83.PubMedGoogle Scholar
  53. 53.
    Huff, J. C., Balfour, H. H., Laskin, O L, Connor, J. D., Corey, L., Bryson, Y. V. and McGuirt, P. (1988) Am. J. Med 85, 84–89.PubMedCrossRefGoogle Scholar
  54. 54.
    Esmann, V., Kroon, S., Peterslund, N. A., Ronne-Rasmussen, J. O., Geil, J. P., Fogh, H., Petersen, C. S. and Danielsen, L. (1987) Lancet 2, 126–129.PubMedCrossRefGoogle Scholar
  55. 55.
    Eaglestein, W. H., Katz, R. and Brown, J. A. (1970) JAMA 211, 1681–1683.CrossRefGoogle Scholar
  56. 56.
    Cobo, M. (1988) Am. J. Med 85, 90–93.PubMedGoogle Scholar
  57. 57.
    Johns, D. R. and Gress, D. R. (1987) Am. J. Med 82 (4), 560–562.PubMedCrossRefGoogle Scholar
  58. 58.
    Stafford, W. and Welch, A. R. (1986) J. Laryngol. Otol. 100, 337–340.PubMedGoogle Scholar
  59. 59.
    Meyers, J. D., Reed, E. C., Shepp, D. H., Thornquist, M., Dandliker, P. S., Vicary, C. A., Flournoy, N., Kirk, L. E., Kersey, J. H., Thomas, D. and Balfour, H. H. (1988) N. Engl. J. Med 318, 70–75.PubMedCrossRefGoogle Scholar
  60. 60.
    Balfour, H. H., Chace, B. A., Stapleton, J. T., Simmons, R. L. and Fryd, D. S. (1989) N. Engl. J. Med 320, 1381–1387.PubMedCrossRefGoogle Scholar
  61. 61.
    Pagano, J. S., Sixbey, J. W. and Lin, J. C. (1983) J Antimicrob. Chemother. 12, 113–121.PubMedGoogle Scholar
  62. 62.
    Andersson, J., Skoldenberg, B., Henle, W., Giesecke, J., Ortqvist, A., Julander, I., Gustaysson, E., Akerlund, B., Brittion, S. and Ernberg, I. (1987) Infection (Munich) 15, S14 — S19.Google Scholar
  63. 63.
    Andersson, J., Britton, S., Ernberg, I., Andersson, U., Henle, W., Skildenberg, B. and Tisell, A. (1986) J. Infect. Dis. 153, 283–288.PubMedCrossRefGoogle Scholar
  64. 64.
    Andersson, J. and Erinberg, I. (1988) Am. J. Med 85, 107–115.PubMedCrossRefGoogle Scholar
  65. 65.
    Straus, S. E., Dale, J. K., Tobi, M., Lawley, T., Preble, O., Blaese, M., Hallahan, C. and Henle, W. (1988) N. Engl. J. Med 319, 1692–1698.PubMedCrossRefGoogle Scholar
  66. 66.
    Hanto, D. W. and Najarian, J. S. (1985) J. Surgical OncoL 30, 215–220.CrossRefGoogle Scholar
  67. 67.
    Sullivan, J. L. (1983) in Advances in Pediatrics, ed. Barness, L. A. ( Year Book Medical ), Vol. 30, pp. 365–394.Google Scholar
  68. 68.
    Resnick, L., Herbst, J. S., Albash, D. V., Atherton, A., Frank, B., Rosen, L. and Horwitz, S. N. (1988) JAMA 259, 384–388.PubMedCrossRefGoogle Scholar
  69. 69.
    Dorsky, D. I. and Crumpacker, C. S. (1987) Ann. Intern. Med 107, 859–874.Google Scholar
  70. 70.
    Bean, B. and Aeppli, D. (1985) J. Infect. Dis. 151, 362–365.PubMedCrossRefGoogle Scholar
  71. 71.
    Whitley, R. J., Alford, C. A., Jr., Hirsch, M. S., Schooley, R. T., Luby, J. P., Aoki, F. Y., Hanley, D., Nahmias, A. J. and MAID Collaborative Antiviral Study Group (1986) N. Engl. J. Med 314, 144–149.CrossRefGoogle Scholar
  72. 72.
    Wade, K. C. and Meyers, J. D. (1983) Ann. Intern. Med 98, 921–925.PubMedGoogle Scholar
  73. 73.
    Andrews, E. B., Tilson, H. H., Hurin, B. A. L., Path, F. R. C. and Cordero, J. F. (1988) Am. J. Med 85, 123–128.PubMedGoogle Scholar
  74. 74.
    Laughlin, C. (1988) NIH Neonatal Consensus Meeting, November 2, 1988.Google Scholar
  75. 75.
    Crumpacker, C. S., Schnipper, L. E., Marlowe, S. I., Kowalsky, P. N., Hershey, B. J. and Levin, M. J. (1982) N Engl. J. Med 306, 343–346.PubMedCrossRefGoogle Scholar
  76. 76.
    Burns, W. H., Saral, R., Santos, G. W., Laskin, O. L., Leitman, P. S., McLaren, C. and Barry, D. W. (1982) Lancet 1, 421–423.PubMedCrossRefGoogle Scholar
  77. 77.
    Coen, D. M. and Schaffer, P. A. (1980) Proc. Natl. Acad. ScL USA 77, 2265–2269.CrossRefGoogle Scholar
  78. 78.
    Larder, B. A. and Darby, S. (1985) Virology 146, 262–271.PubMedCrossRefGoogle Scholar
  79. 79.
    Darby, G., Field, H. J. and Salisbury, S. A. (1981) Nature (London) 289, 81–83.CrossRefGoogle Scholar
  80. 80.
    Field, H. J. and Darby, G. (1980) Antimicrob. Agents Chemother. 17, 209–216.PubMedGoogle Scholar
  81. 81.
    Erlich, S. K., Mills, J., Chatis, P., Mertz, G. J., Busch, D. F., Follansbee, S. E., Grant, R. M. and Crumpacker, C. S. (1989) N. Engl J. Med 320, 293–296.PubMedCrossRefGoogle Scholar
  82. 82.
    Pawaha, S., Biron, K., Lim, W., Swenson, P., Kaplan, M. H., Sadick, N. and Pahsa, R. (1988) JAMA 260, 2879–2882.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Richard J. Whitley
    • 1
    • 2
  • Mark Middlebrooks
    • 1
    • 2
  • John W. GnannJr.
    • 2
  1. 1.Departments of PediatricsUniversity of Alabama at BirminghamBirminghamUSA
  2. 2.Departments of MedicineUniversity of Alabama at BirminghamBirminghamUSA

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