Mechanisms of Restriction of Viral Gene Expression during Herpes Simplex Virus Latency

  • Amy E. Sears
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 278)


The basic biological phenomena of herpes simplex virus (HSV) infections in man have been described in detail for many years. At the time of primary infection, the virus replicates lytically in the peripheral tissues around the site of infection, and enters sensory nerves through the termini of axons of sensory neurons. Latent infection is established in the neurons of sensory ganglia (1); during this phase, no infectious virus can be detected. Periodically, various stimuli including stress, exposure to ultraviolet light, and hormonal changes induce reactivation and production of infectious virus. The reactivated virus then travels back to the tissues around the site of the primary infection, where it again replicates lytically, destroying cells and causing the formation of recurrent lesions.


Herpes Simplex Virus Thymidine Kinase Trigeminal Ganglion Latent Infection Recombinant Virus 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Amy E. Sears
    • 1
  1. 1.Marjorie B. Kovler Viral Oncology LaboratoriesUniversity of ChicagoChicagoUSA

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