Pathogenesis and Latency of Herpes Simplex Virus Type 1 (HSV-1): An Ophthalmologist’s View of the Eye as a Model for the Study of the Virus-Host Relationship

  • Y. Jerold Gordon
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 278)


The current overview presents HSV-1 pathogenicity and latency from the point of view of a practicing ophthalmologist. It begins with the premise that “man is the measure of all things.” The devastation wrought by herpes simplex virus type 1 (HSV-1) in the human eye is both significant and widespread. HSV-1 is the leading infectious cause of corneal blindness in the industrialized world, and there are over 300,000 cases of herpetic eye infection annually in the United States (1). Our goal in ophthalmology is to reduce and ultimately prevent the visual loss due to herpes simplex eye infections.


Herpes Simplex Trigeminal Ganglionic Zealand Rabbit Ocular Infection Epithelial Keratitis 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Y. Jerold Gordon
    • 1
  1. 1.Eye and Ear Institute of PittsburghUniversity of PittsburghPittsburghUSA

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