Transcripts Associated with Herpes Simplex Virus Latency

  • Jack G. Stevens
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 278)


It has been almost 20 years since herpes simplex virus type 1 (HSV-1) was first shown to establish latent infections in the neurons of sensory ganglia (1). As might be expected, a considerable amount of work on the latent state followed this finding. In spite of the volume of work which has been published, the mechanisms employed by the agent and cell in establishing, maintaining, and reactivating from this state are just now beginning to be understood. The reasons for this extended period of relative ignorance relate principally to the complexities and difficulties of manipulating both virus and host cell. The virus has a complex morphological structure with a unique DNA arrangement, and it replicates in an involved fashion in which there is a temporal appearance of transcripts and protein products that arise from some 72 different viral genes (reviewed in [2]). The host cell is a member of a group of cells which is among the most poorly understood within the mammalian body, and they continue to be difficult to isolate, maintain, and study in vitro.


Trigeminal Ganglion Latent Infection Transcription Unit Sensory Ganglion Infected Neuron 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Stevens, J. G. & Cook, M. L. (1971) Science (Washington, D.C., 1883-) 173, 843.CrossRefGoogle Scholar
  2. 2.
    McGeoch, D. J., Dalymple, M. A., Davison, A. J., Dolan, A., Frame, M. C., McNab, D., Perry, L. J., Scott, J. E. & Taylor, P. (1988) J. Gen. Virol. 69, 1531–1574.PubMedCrossRefGoogle Scholar
  3. 3.
    Stevens, J. G. (1989) Cur. Top. MicrobioL Immunol. 143, 1–8.CrossRefGoogle Scholar
  4. 4.
    Galloway, D. A., Fenoglio, C. M. & McDougall, J. K. (1982) J. Virol. 41, 686–691.PubMedGoogle Scholar
  5. 5.
    Tenser, R. B., Ressel, S. J. & Dunston, M. E. (1984) Ann. Neurol. 11, 285–291.CrossRefGoogle Scholar
  6. 6.
    Stroop, W. G., Rock, D. L. & Fraser, N. W. (1984) Lab. Invest. 51, 27–38.PubMedGoogle Scholar
  7. 7.
    Stevens, J. G., Wagner, E. K., Devi-Rao, G. B., Cook, M. L. & Feldman, L. T. (1987) Science (Washington, D.C., 1883-) 235, 1056–1059.CrossRefGoogle Scholar
  8. 8.
    Stevens, J. G. (1989) MicrobioL Rev. 53, 318–332.PubMedGoogle Scholar
  9. 9.
    Wagner, E., Devi-Rao, G. B., Feldman, L. T., Dobson, A., Zhang, Y.-F., Flanagan, M. & Stevens, J. G. (1988) J. Viral. 62, 1194–1202.Google Scholar
  10. 10.
    Wagner, E. K., Flanagan, W. M., Davi-Rao, G., Zhang, Y.-F., Hill, J. M., Anderson, K. P. & Stevens, J. G. (1988) J. Viral. 62, 4577–4585.Google Scholar
  11. 11.
    Dobson, A. T., Sedarati, F., Devi-Rao, G., Flanagan, W. M., Farrell, M. J., Stevens, J. G., Wagner, E. K. & Feldman, L. T. (1989) J. Virol. 63, 3844–3851.PubMedGoogle Scholar
  12. 12.
    Javier, R. T., Stevens, J. G., Dissette, V. B. & Wagner, E. K. (1988) Virology 166, 254–257.PubMedCrossRefGoogle Scholar
  13. 13.
    Steiner, I., Spivak, J. G., Lirette, R. P., Brown, S. M., MacLean, A. R., Suuak-Sharpe, J. H. & Fraser, N. W. (1989) EMBO J. 8, 505–511.PubMedGoogle Scholar
  14. 14.
    Leib, D. A., Bogard, C. L., Kosz-Vrenchak, M., Hides, K. A., Cohen, D. M., Knipe, D. M. & Schaffer, P. A. (1989) J. Virol. 63, 2893–2900.PubMedGoogle Scholar
  15. 15.
    Sedarati, F., Izumi, K. M., Wagner, E. K. & Stevens, J. G. (1989) J. Virol. 63, 4455–4458.PubMedGoogle Scholar
  16. 16.
    Ho, D. Y. & Mocarski, E. S. (1989) Proc. Neal Acad. Sci. USA 86, 7596–7600.CrossRefGoogle Scholar
  17. 17.
    Hall, J. M., Sedarati, F., Javier, R. T., Wagner, E. K. & Stevens, J. G. (1990) Virology 174, 117–125.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Jack G. Stevens
    • 1
  1. 1.Department of Microbiology and ImmunologyUniversity of California, Los Angeles, School of MedicineLos AngelesUSA

Personalised recommendations