On the Biology of Epstein-Barr Virus Persistence: A Reappraisal

  • A. B. Rickinson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 278)


One of the central unsolved questions of Epstein-Barr virus (EBV) biology is the mechanism of virus persistence in the immunologically competent host. In vitro this virus displays potent growth-transforming activity for one of its major target cells, the B lymphocyte; in vivo virus infection of the B-cell pool appears to be very largely asymptomatic. Much current work on the biology and immunology of EBV infection is aimed at resolving this apparent paradox. The present paper reviews recent progress in the field and develops a provisional model for asymptomatic EBV persistence. The principal gaps in our knowledge will be identified as a stimulus for future work.


Latent Membrane Protein Lytic Cycle Target Epitope Latent Membrane Protein Expression Phorbol Ester Treatment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • A. B. Rickinson
    • 1
  1. 1.Cancer Research Campaign Laboratories, Department of Cancer StudiesUniversity of BirminghamBirminghamUK

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