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On the Biology of Epstein-Barr Virus Persistence: A Reappraisal

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Immunobiology and Prophylaxis of Human Herpesvirus Infections

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 278))

Abstract

One of the central unsolved questions of Epstein-Barr virus (EBV) biology is the mechanism of virus persistence in the immunologically competent host. In vitro this virus displays potent growth-transforming activity for one of its major target cells, the B lymphocyte; in vivo virus infection of the B-cell pool appears to be very largely asymptomatic. Much current work on the biology and immunology of EBV infection is aimed at resolving this apparent paradox. The present paper reviews recent progress in the field and develops a provisional model for asymptomatic EBV persistence. The principal gaps in our knowledge will be identified as a stimulus for future work.

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Author information

Authors and Affiliations

  1. Cancer Research Campaign Laboratories, Department of Cancer Studies, University of Birmingham, Birmingham, UK

    A. B. Rickinson

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  1. A. B. Rickinson
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Editor information

Editors and Affiliations

  1. Eli Lilly and Company, Indianapolis, Indiana, USA

    Carlos Lopez

  2. Kyushu University, Fukuoka, Japan

    Ryoichi Mori

  3. The University of Chicago, Chicago, Illinois, USA

    Bernard Roizman

  4. University of Alabama at Birmingham, Birmingham, Alabama, USA

    Richard J. Whitley

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© 1990 Plenum Press, New York

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Rickinson, A.B. (1990). On the Biology of Epstein-Barr Virus Persistence: A Reappraisal. In: Lopez, C., Mori, R., Roizman, B., Whitley, R.J. (eds) Immunobiology and Prophylaxis of Human Herpesvirus Infections. Advances in Experimental Medicine and Biology, vol 278. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5853-4_14

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  • DOI: https://doi.org/10.1007/978-1-4684-5853-4_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5855-8

  • Online ISBN: 978-1-4684-5853-4

  • eBook Packages: Springer Book Archive

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