Carcinogenicity of Complex Mixtures in Air Using In Vitro and In Vivo Assays

  • I. Chouroulinkov
Part of the Environmental Science Research book series (ESRH, volume 39)


The relationship between the environmental chemicals and the increase of lung cancer in man is now well established. In fact, the first occupational cancer reported by Pott in 1775 (23,24) was caused by a complex mixture of coal soot. In this case the soot in contact for long periods with the scrotal skin of chimney sweeps induced local irritation and squamous cell carcinoma. We can also cite the epidemiological evidence for a correlation between the increase of lung cancer and exposure to cigarette smoke and industrially polluted atmospheres (12–14).


Skin Test Diesel Exhaust Sebaceous Gland Sister Chromatid Exchange Epidermal Hyperplasia 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • I. Chouroulinkov
    • 1
  1. 1.Cancer Research InstituteCNRSVillejuif CédexFrance

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