Characterization of Mutagen Sources in Urban Particulate Matter in Gothenburg, Sweden
The modern interest in urban air pollution emerged in the early 1950s. Kotin and coworkers (14) were the first to collect samples of airborne particulate matter and use extracts in an animal tumorigenicity assay. These studies seem partly due to a hypothesis that the urban air pollution was a major factor causing the increased lung cancer incidence observed at that time, although data were emerging showing that lung cancer is due largely to tobacco smoking (31). Studies on the carcinogenicity of urban air pollutants continued at a slow pace through the 1960s and early 1970s (9,10). An enhanced interest in the problem started in the latter part of the 1970s when more sophisticated analytical methods became available and the Ames Salmonella mutagenicity assay was shown to be useful for urban air samples (8,20,24,27).
KeywordsPolycyclic Aromatic Hydrocarbon Airborne Particulate Matter Mutagenic Response Mass Balance Method Motor Vehicle Exhaust
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