Evaluation of DNA Binding In Vivo for Low-Dose Extrapolation in Chemical Carcinogenesis
The exposure of the human population to unavoidable carcinogens is in a dose range which would not give rise to a significant increase of the tumor incidence in a standard bioassay for carcinogenicity with laboratory animals. This lack of sensitivity of the bioassay is largely due to the limitations in the number of animals used and the variability of the tumor incidence both in control and treated groups (5). Therefore, in order to estimate the “virtually safe” dose which should not lead to more than one additional tumor in one million people exposed, four to five orders of magnitude must be spanned with extrapolations.
KeywordsTumor Incidence Tumor Induction Lower Dose Level High Performance Liquid Chromato High Performance Liquid Chromato
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