Protein Adducts as Biomarkers for Chemical Carcinogens
Protein adducts are one of several types of biomarkers which are valuable to the study of chemical carcinogenesis (8). Over the last 15 years, a great deal of developmental work has gone into making this particular biomarker a useful one. Much of the effort has been focused on hemoglobin as the target protein, but serum albumin has also proven interesting. Enough laboratory experiments and studies of human subjects have now been conducted that it is worthwhile to reflect on the results to attempt an assessment of the role protein adducts can play in the study of chemical carcinogenesis. This chapter specifically addresses issues related to epidemiological studies.
KeywordsPolycyclic Aromatic Hydrocarbon Environmental Tobacco Smoke Systemic Dose Adduct Level Protein Adduct
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