32P-Postlabeling DNA Adduct Assay: Cigarette Smoke-Induced DNA Adducts in the Respiratory and Nonrespiratory Rat Tissues
Several epidemiological studies have strongly implicated cigarette smoking with higher incidence of respiratory tract cancer including those of larynx, the oral cavity, and the lung (4). In addition, smokers face an increased risk for cancer of the pancreas and bladder, among other organs (14,20).
KeywordsCigarette Smoke Adduct Level Mainstream Smoke Total Particulate Matter Aryl Hydrocarbon Hydroxylase
Unable to display preview. Download preview PDF.
- 3.Dontenwill, W.P. (1974) Tumorigenic effect of chronic cigarette smoke inhalation on Syrian golden hamster. In Experimental Lung Cancer. Carcinogenesis and Bioassays, E. Karbe and E. Park, eds. Springer-Verlag, New York, pp. 331–368.Google Scholar
- 6.Garg, A., and R.C. Gupta (1988) Tissue-specific DNA modifications in untreated, aged rats as detected by 32P-adduct assay. Proc. Am. Assoc. Cancer Res. 29:104.Google Scholar
- 14.International Agency for Research on Cancer Tobacco Smoking (1986) IARC Monograph 38:199–293.Google Scholar
- 18.Schneider, E.L. (1985) Cytogenetics of aging. In Handbook of the Biology of Aging, C.E. Finch and E.L. Schnieder, eds. Van Nostrand Reinhold, New York, pp. 357–373.Google Scholar
- 19.Scmookler-Reiss, R.J., and S. Goldstein (1985) Genetic diversification and the clonality of senscence. In Review of Biological Research in Aging, Vol. 2, M. Rothstein, ed. Alan R. Liss, New York, pp. 115–139.Google Scholar
- 20.U.S. Surgeon General (1982) The Health Consequences of Smoking—Cancer (PHS) 82–50179:5–8.Google Scholar
- 22.Wynder, E.L., and D. Hoffman (1967) Tobacco and Tobacco Smoke-studies in Experimental Carcinogenesis. Academic Press, New York, pp. 730–752.Google Scholar