DNA Adducts and Related Biomarkers in Assessing the Risk of Complex Mixtures

  • F. P. Perera
  • P. Schulte
  • R. M. Santella
  • D. Brenner
Part of the Environmental Science Research book series (ESRH, volume 39)


Risk assessment for complex mixtures is not merely a theoretical problem but a “real-life” one. Most common human exposures involve multiple chemicals and agents in combination. To illustrate, cigarette smoke contains more than 3,800 different chemicals including at least 40 carcinogens (i.e., known human or animal carcinogens) (41). More than 300 different toxic chemicals, including approximately 50 carcinogens, have been detected both in ambient air (18, 56) and in drinking water (29).


Polycyclic Aromatic Hydrocarbon Complex Mixture Ethylene Oxide Propylene Oxide Coke Oven 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • F. P. Perera
    • 1
  • P. Schulte
    • 2
  • R. M. Santella
    • 1
  • D. Brenner
    • 3
  1. 1.Columbia University School of Public HealthNew YorkUSA
  2. 2.National Institute of Occupational Safety and HealthCincinnatiUSA
  3. 3.Environmental Health InstitutePittsfieldUSA

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