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Mutagenicity, Carcinogenicity, and Human Cancer Risk from Indoor Exposure to Coal and Wood Combustion in Xuan Wei, China

  • Judy L. Mumford
  • Robert S. Chapman
  • Stephen Nesnow
  • C. Tuker Helmes
  • Xueming Li
Part of the Environmental Science Research book series (ESRH, volume 39)

Abstract

The residents in Xuan Wei County, China, have been exposed to high levels of combustion emissions from smoky and smokeless coal and wood combustion under unvented conditions in homes. An unusually high lung cancer mortality rate that cannot be attributed to tobacco smoke or occupational exposure was found. The communes using smoky coal, which emits more organics than smokeless coal, generally have a higher lung cancer rate than the communes using smokeless coal or wood. The mutagenicity and carcinogencity of organic extracts of indoor air particles collected from Xuan Wei homes during cooking were investigated. The objectives of this study were: (i) to investigate the characteristics of lung cancer mortality in Xuan Wei, (ii) to determine the genotoxicity and chemical and physical properties of the combustion emissions, and (iii) to link bioassay results to human lung cancer data. The organic extracts of these emission particles were, tested for mutagenicity in the Ames Salmonella and the L5178Y TK+/− mouse lymphoma assays, and for skin tumor-initiating activity and complete carcinogencity in SENCAR mice. The two coal samples showed higher activity in both mutagenicity and tumor initiation. When the emission rate of organics was taken into consideration, the smoky coal emission showed the highest potency of the three fuels. The smoky coal sample was also a more potent complete carcinogen than the wood sample. Higher mutagenicity and carcinogenicity of the smoky coal emission compared to wood or smokeless coal emissions are in agreement with the epidemiological data.

Keywords

Lung Cancer Organic Extract Lung Cancer Mortality Wood Combustion Combustion Emission 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Ames, B.W., J.M. McCann, and E. Yamasaki (1975) Methods for detecting carcinogens and mutagens with the Salmonella/mammalian microsome mutagenicity test. Mutat. Res. 31:347–364.PubMedGoogle Scholar
  2. 2.
    Clive, D., K.O. Johnson, J.F.S. Spector, A.G. Batson, and M.M.M. Brown (1979) Validation and characterization of the L5178Y TK+/‒ mouse lymphoma mutagen assay system. Mutat. Res. 59:61–108.PubMedCrossRefGoogle Scholar
  3. 3.
    He, X.Z., S.R. Cao, W.Z. Jiang, R.D. Yang, and C.W. Xu (1986) Research on Etiology of Lung Cancer in Xuan Wei. Institute of Environmental Health and Engineering, Chinese Academy of Preventive Medicine, Beijing, China.Google Scholar
  4. 4.
    International Agency for Research on Cancer (1983) Polynuclear aromatic compounds: Chemical, environmental, and experimental data. In IARC Monographs on the Evaluation of the Carcinogenic Risks of Chemicals to Humans, Vol, 32, Part 1:95–447. International Agency for Research on Cancer, Lyon, France.Google Scholar
  5. 5.
    International Agency for Research on Cancer (1986) Tobacco smoking. In IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Humans, Vol. 38. International Agency for Research on Cancer, Lyon, France.Google Scholar
  6. 6.
    International Agency for Research on Cancer (1984) Polycyclic aromatic compounds, industrial exposures in aluminum production, coal gasification, coke production, and iron and steel founding. In IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, Vol. 34, Part 3. International Agency for Research on Cancer, Lyon, France, pp. 107–108.Google Scholar
  7. 7.
    LI, J.Y., et al., eds. (1979) Atlas of cancer Mortality in the People’s Republic of China, China Map Press, Shanghai, China.Google Scholar
  8. 8.
    Mumford, J.L., X.Z. He, R.S. Chapman, S.R. Cao, D.B. Harris, X.M. Li., Y.L. Xian, W.Z. Jiang, C.W. Xu, J.C Chuang, W.E. Wilson, and M. Cooke (1987) Lung cancer and indoor air pollution in Xuan Wei, China. Science 235:217–220.Google Scholar
  9. 9.
    Mumford, J.L., X. He, and R.S. Chapman (1989) Human lung cancer risks due to complex organic mixtures of combustion emissions. In Recent Results in Cancer Research, P. Band, ed. Springer-Verlag, New York (in press).Google Scholar
  10. 10.
    Mumford, J.L., C.T. Helmes, X. Lee, L. Seidenberg, and S. Nesnow (1989) Mouse skin tumorigenicity studies of indoor coal and wood combustion emissions from homes of residents in Xuan Wei, China, with high lung cancer mortality. Carcinogenesis (in press).Google Scholar
  11. 11.
    Pott, P. (1775) Chirurgical observations relative to the cataract, the polypus of the nose, the cancer of the scrotum, the different kinds of ruptures, and the modifications of the toes and feet. In The Chirurgical Works of Percivall Pott, Vol. 5, L. Hawes, W. Clarke, and R. Collins, eds. London.Google Scholar
  12. 12.
    Tennant, W.R., B.H. Margolin, M.D. Shelby, E. Zeiger, J.K. Haseman, J. Spalding, W. Caspary, M. Reshick, S. Stasiewicz, B. Anderson, and R. Minor (1987) Prediction of chemical carcinogenicity in rodents from in vitro genetic toxicity assays. Science 236:933–941.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Judy L. Mumford
    • 1
  • Robert S. Chapman
    • 1
  • Stephen Nesnow
    • 1
  • C. Tuker Helmes
    • 2
  • Xueming Li
    • 3
  1. 1.U.S. Environmental Protection AgencyResearch Triangle ParkUSA
  2. 2.SRI InternationalMenlo ParkUSA
  3. 3.Institute of Environmental Health and EngineeringBeijingChina

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