Analysis of Dopamine and Neuropeptides in 6-OHDA-Lesioned Rats
Cholecystokinin (CCK) and dopamine (DA) coexist in the ventral tegmental area and medial substantia nigra neurons.1 In the brain of Parkinson’s disease patients, a prominent decrease in CCK content of the substantia nigra has been reported,2 and it is thought that DA and CCK might be related to the etiology of Parkinson’s disease. The precise functional interaction between DA and CCK, however, is not clarified. Based on the hypothesis that CCK has a functional role as one of the modulators of DA metabolism, ceruletide (CLT), which is a CCK-related decapeptide, is currently under trial for the treatment of diseases with involuntary movements including Parkinson’s disease.3 In the present study we attempted to clarify the mechanism of action of CLT and CCK with respect to their receptors as well as their effect on behavior in a Parkinson’s disease model, namely, the 6-OHDA unilaterally lesioned rat.
KeywordsNucleus Accumbens Ventral Tegmental Area Lesion Side Autoradiographic Analysis Brain Microdialysis
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